SCHEMBL4319722

SCHEMBL4319722

CCOC(=O)C1c2ccccc2C(=O)N1C1CCOCC1

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 1/20 0.53
ALDH1A1 P00352 10/20 0.51
MAPT P10636 3/20 0.51
ALOX15 P16050 1/20 0.51
POLB P06746 1/20 0.49
NPSR1 Q6W5P4 2/20 0.48
MEN1 O00255 1/20 0.48
GAA P10253 1/20 0.48
KMT2A Q03164 1/20 0.48
MAPK1 P28482 1/20 0.47
TSHR P16473 4/20 0.46
L3MBTL1 Q9Y468 4/20 0.46
HPGD P15428 3/20 0.46
HSD17B10 Q99714 3/20 0.46
KDM4E B2RXH2 1/20 0.45
HTT P42858 2/20 0.43
LMNA P02545 1/20 0.43
ATM Q13315 1/20 0.43
CYP2D6 P10635 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4317569 0.85 SCN9A (0.56) SCN9AALDH1A1MAPTALOX15NPSR1
SCHEMBL4327202 0.81 SCN9A (0.54) SCN9AALDH1A1MAPTALOX15POLB
SCHEMBL4317906 0.80 SCN9A (0.37) SCN9AALDH1A1MAPTALOX15POLB
SCHEMBL13577812 0.80 NPC1 (0.61) ALDH1A1MAPTALOX15NPSR1MEN1
SCHEMBL4330606 0.78 ALDH1A1 (0.44) ALDH1A1MAPTALOX15NPSR1MEN1
SCHEMBL4325025 0.77 KCNH2 (0.59) SCN9AALDH1A1MAPTALOX15POLB
SCHEMBL14790130 0.76 ALDH1A1 (0.53) ALDH1A1MAPTALOX15POLBMEN1
SCHEMBL1888404 0.75 FFAR1 (0.50) ALDH1A1MAPTALOX15POLBGAA
SCHEMBL4316853 0.74 SCN9A (0.67) SCN9AALDH1A1POLBTSHRCYP2D6
SCHEMBL13577839 0.73 SCN9A (0.75) SCN9AALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009145720-A1 ISOINDOLINE DERIVATIVES COMPRISING ADDITIONAL HETEROCYCLIC GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS ASTRAZENECA AB (SE) 2009-12-03 WO disclosed
WO-2009145720-A1 ISOINDOLINE DERIVATIVES COMPRISING ADDITIONAL HETEROCYCLIC GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS ASTRAZENECA AB (SE) 2009-12-03 WO disclosed
WO-2009145721-A1 ISOINDOLINE DERIVATIVES COMPRISING PHENYL GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS ASTRAZENECA AB (SE) 2009-12-03 WO disclosed
WO-2009145721-A1 ISOINDOLINE DERIVATIVES COMPRISING PHENYL GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS ASTRAZENECA AB (SE) 2009-12-03 WO disclosed