SCHEMBL4317569

SCHEMBL4317569

CCOC(=O)C1c2ccccc2C(=O)N1C1CCC(F)(F)CC1

nearest known ligand 0.56

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 3/20 0.56
KCNH2 Q12809 2/20 0.56
SCN5A Q14524 2/20 0.56
ALDH1A1 P00352 8/20 0.50
MAPT P10636 3/20 0.50
ALOX15 P16050 1/20 0.50
NPSR1 Q6W5P4 2/20 0.48
MEN1 O00255 1/20 0.48
GAA P10253 1/20 0.48
KMT2A Q03164 1/20 0.48
TSHR P16473 4/20 0.46
HPGD P15428 2/20 0.46
HSD17B10 Q99714 2/20 0.46
L3MBTL1 Q9Y468 2/20 0.46
KDM4E B2RXH2 1/20 0.44
MAPK1 P28482 1/20 0.42
HTT P42858 1/20 0.42
PARP1 P09874 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4319722 0.85 SCN9A (0.53) SCN9AALDH1A1MAPTALOX15NPSR1
SCHEMBL4318494 0.83 SCN9A (0.57) SCN9AKCNH2SCN5AALDH1A1MAPT
SCHEMBL4321153 0.81 PARP1 (0.42) SCN9AKCNH2SCN5AALDH1A1MAPT
SCHEMBL4330606 0.77 ALDH1A1 (0.44) ALDH1A1MAPTALOX15NPSR1MEN1
SCHEMBL13577812 0.77 NPC1 (0.61) ALDH1A1MAPTALOX15NPSR1MEN1
SCHEMBL4325025 0.76 KCNH2 (0.59) SCN9AKCNH2SCN5AALDH1A1MAPT
SCHEMBL13577808 0.76 SCN9A (0.80) SCN9AKCNH2SCN5AALDH1A1
SCHEMBL14790130 0.75 ALDH1A1 (0.53) ALDH1A1MAPTALOX15MEN1KMT2A
SCHEMBL4331746 0.74 SCN9A (0.56) SCN9AKCNH2SCN5AALDH1A1MAPT
SCHEMBL1888404 0.74 FFAR1 (0.50) ALDH1A1MAPTALOX15GAATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009145720-A1 ISOINDOLINE DERIVATIVES COMPRISING ADDITIONAL HETEROCYCLIC GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS ASTRAZENECA AB (SE) 2009-12-03 WO disclosed
WO-2009145720-A1 ISOINDOLINE DERIVATIVES COMPRISING ADDITIONAL HETEROCYCLIC GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS ASTRAZENECA AB (SE) 2009-12-03 WO disclosed
WO-2009145721-A1 ISOINDOLINE DERIVATIVES COMPRISING PHENYL GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS ASTRAZENECA AB (SE) 2009-12-03 WO disclosed
WO-2009145721-A1 ISOINDOLINE DERIVATIVES COMPRISING PHENYL GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS ASTRAZENECA AB (SE) 2009-12-03 WO disclosed