Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | EPOR | P19235 | 8/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4320181 | 0.87 | CHRM4 (0.48) | CHRM4KCNH2EPORLTA4HHDAC1 | |
| SCHEMBL4327986 | 0.86 | KCNH2 (0.45) | CHRM4KCNH2EPOREGFRERBB2 | |
| SCHEMBL4320373 | 0.85 | EPOR (0.52) | CHRM4KCNH2EPORLTA4HHDAC1 | |
| Trifluoroacetic Acid SCHEMBL4320176 | 0.83 | LTA4H (0.53) | CHRM4KCNH2EPORLTA4HHDAC1 | |
| Trifluoroacetic Acid SCHEMBL1134632 | 0.82 | KCNH2 (0.67) | CHRM4KCNH2EPORREN | |
| SCHEMBL4320367 | 0.81 | LTA4H (0.59) | CHRM4KCNH2EPORLTA4HHDAC1 | |
| SCHEMBL1134581 | 0.80 | KCNH2 (0.72) | CHRM4KCNH2EPOR | |
| Trifluoroacetic Acid SCHEMBL4327980 | 0.78 | PPARG (0.45) | CHRM4KCNH2EPOR | |
| SCHEMBL4327817 | 0.75 | EPOR (0.55) | EPORLTA4H | |
| SCHEMBL4325933 | 0.74 | EPOR (0.48) | CHRM4KCNH2EPORHDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8664228-B2 | 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid derivatives and their use as epithelial sodium channel blockers for the treatment of airway diseases | NOVARTIS AG (CH) | 2014-03-04 | — | — | US | disclosed |
| EP-2285785-B1 | 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ARWAY DISEASES | NOVARTIS AG (CH) | 2012-09-05 | — | — | EP | disclosed |
| WO-2009138378-A1 | 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ARWAY DISEASES | NOVARTIS AG (CH) | 2009-11-19 | — | — | WO | disclosed |