Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPOR | P19235 | 5/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4327980 | 0.94 | PPARG (0.45) | EPORPPARGCHRM4KCNH2SIRT2 | |
| SCHEMBL4320367 | 0.84 | LTA4H (0.59) | EPORCHRM4KCNH2HDAC1HDAC7 | |
| SCHEMBL4327986 | 0.82 | KCNH2 (0.45) | EPORCHRM4KCNH2HDAC1HDAC7 | |
| SCHEMBL4320373 | 0.80 | EPOR (0.52) | EPORCHRM4KCNH2HDAC1HDAC7 | |
| Trifluoroacetic Acid SCHEMBL4320176 | 0.79 | LTA4H (0.53) | EPORCHRM4KCNH2HDAC1HDAC7 | |
| SCHEMBL2076563 | 0.77 | KCNH2 (0.67) | EPORCHRM4KCNH2 | |
| SCHEMBL7653534 | 0.76 | GPR34 (0.57) | — | |
| Trifluoroacetic Acid SCHEMBL4320181 | 0.75 | CHRM4 (0.48) | EPORCHRM4KCNH2HDAC1HDAC7 | |
| SCHEMBL4320178 | 0.74 | CHRM4 (0.47) | EPORCHRM4KCNH2HDAC1HDAC7 | |
| SCHEMBL4327813 | 0.74 | LTA4H (0.60) | EPOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009138378-A1 | 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ARWAY DISEASES | NOVARTIS AG (CH) | 2009-11-19 | — | — | WO | claimed |
| US-8664228-B2 | 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid derivatives and their use as epithelial sodium channel blockers for the treatment of airway diseases | NOVARTIS AG (CH) | 2014-03-04 | — | — | US | disclosed |
| WO-2009138378-A1 | 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ARWAY DISEASES | NOVARTIS AG (CH) | 2009-11-19 | — | — | WO | disclosed |