Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 14/20 | 0.62 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TYMS | P04818 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5081902 | 0.81 | HTR3A (0.45) | PDE5AHTR3AHRH4NPC1ALDH1A1 | |
| SCHEMBL5595129 | 0.81 | PDE5A (0.52) | PDE5AHTR3AHRH4PKMGAA | |
| Hydrochloric Acid SCHEMBL7278529 | 0.80 | PDE5A (0.53) | PDE5AHTR3AHRH4PKMGAA | |
| SCHEMBL7442498 | 0.79 | PDE5A (0.77) | PDE5AHTR3AHRH4MEN1KMT2A | |
| SCHEMBL4652135 | 0.78 | PDE5A (0.49) | PDE5AHTR3AHRH4PKMKMT2A | |
| SCHEMBL3977603 | 0.77 | PDE5A (0.70) | PDE5AHTR3AHRH4MEN1KMT2A | |
| SCHEMBL2590769 | 0.77 | RAD52 (0.68) | PDE5AHTR3AHRH4PKMKMT2A | |
| SCHEMBL3638867 | 0.77 | PDE5A (0.73) | PDE5AHTR3AHRH4PKMKMT2A | |
| SCHEMBL432876 | 0.76 | PDE5A (1.00) | PDE5AMEN1KMT2AGAAMAPT | |
| SCHEMBL1083888 | 0.76 | MAPK1 (0.73) | PDE5AHTR3AHRH4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009013286-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-01-29 | — | — | WO | claimed |
| EP-1890699-A1 | INDACTEROL DERIVATIVES AND PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF AIRWAY DISEASES | Novartis AG (CH) | 2008-02-27 | — | — | EP | claimed |
| WO-2006128675-A1 | INDACTEROL DERIVATIVES AND PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF AIRWAY DISEASES | NOVARTIS AG (CH) | 2006-12-07 | — | — | WO | claimed |
| JP-2002532542-A | — | — | 2002-10-02 | — | — | JP | claimed |
| EP-1140044-A2 | cGMP PDE 5 INHIBITORS FOR INHALATION IN THE TREATMENT OF SEXUAL DYSFUNCTION | Novartis AG (CH) | 2001-10-10 | — | — | EP | claimed |
| WO-2000037061-A2 | cGMP PDE 5 INHIBITORS FOR INHALATION IN THE TREATMENT OF SEXUAL DYSFUNCTION | NOVARTIS AG (CH) | 2000-06-29 | — | — | WO | claimed |
| EP-2755708-A2 | INHALER | Astrazeneca AB (SE) | 2014-07-23 | — | — | EP | disclosed |
| EP-2755707-A1 | INHALER | Astrazeneca AB (SE) | 2014-07-23 | — | — | EP | disclosed |
| EP-2595683-A2 | INHALER | AstraZeneca AB (SE) | 2013-05-29 | — | — | EP | disclosed |
| EP-2595684-A1 | INHALER | AstraZeneca AB (SE) | 2013-05-29 | — | — | EP | disclosed |
| WO-2013038170-A2 | INHALER | ASTRAZENECA AB (SE) | 2013-03-21 | — | — | WO | disclosed |
| WO-2013038169-A1 | INHALER | ASTRAZENECA AB (SE) | 2013-03-21 | — | — | WO | disclosed |
| EP-2534054-A1 | PROCESS FOR PROVIDING A FILLED CANISTER FOR AN INHALER | AstraZeneca UK Limited (GB) | 2012-12-19 | — | — | EP | disclosed |
| WO-2009154562-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A 4-HYDROXY-2-OXO-2, 3- DIHYDRO-1, 3-BENZOTHIAZOL-7-YL COMPOUND FOR MODULATION OF BETA2-ADRENORECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2009-12-23 | — | — | WO | disclosed |
| WO-2009037503-A2 | NEW COMBINATION - 012 FOR THE TREATMENT OF RESPIRATORY DISEASES | ASTRAZENECA AB (SE) | 2009-03-26 | — | — | WO | disclosed |
| WO-2009013286-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-01-29 | — | — | WO | disclosed |
| EP-1890699-A1 | INDACTEROL DERIVATIVES AND PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF AIRWAY DISEASES | Novartis AG (CH) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006128675-A1 | INDACTEROL DERIVATIVES AND PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF AIRWAY DISEASES | NOVARTIS AG (CH) | 2006-12-07 | — | — | WO | disclosed |
| EP-1140044-A2 | cGMP PDE 5 INHIBITORS FOR INHALATION IN THE TREATMENT OF SEXUAL DYSFUNCTION | Novartis AG (CH) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037061-A2 | cGMP PDE 5 INHIBITORS FOR INHALATION IN THE TREATMENT OF SEXUAL DYSFUNCTION | NOVARTIS AG (CH) | 2000-06-29 | — | — | WO | disclosed |