Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.68 |
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | QPCT | Q16769 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | LTA4H | P09960 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15224205 | 0.82 | KMT2A (0.68) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL4325474 | 0.81 | MEN1 (0.67) | KMT2AMEN1CYP1A2CYP2C19QPCT | |
| SCHEMBL4322685 | 0.80 | MAPK1 (0.58) | KMT2ACYP1A2CYP2C19ALDH1A1LMNA | |
| SCHEMBL4319602 | 0.79 | LTA4H (0.55) | KMT2AMEN1CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL4319604 | 0.79 | LTA4H (0.55) | KMT2AMEN1CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL25181231 | 0.79 | KMT2A (0.76) | KMT2AMEN1CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL5051514 | 0.79 | KMT2A (0.56) | KMT2AMEN1CYP1A2CYP2C19QPCT | |
| SCHEMBL3424405 | 0.78 | MEN1 (0.74) | KMT2AMEN1CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL4318327 | 0.77 | GAA (0.57) | KMT2AMEN1CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL3628440 | 0.77 | QPCT (1.00) | KMT2AMEN1CYP1A2CYP2C19QPCT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582656-B2 | Guanidine derivatives and therapeutic uses thereof | MERCK PATENT GESELLSCHAFT (DE) | 2009-09-01 | — | — | US | disclosed |
| US-20080004315-A1 | Guanidine Derivatives and Therapeutic Uses Thereof | MERCK PATENT GMBH (DE) | 2008-01-03 | — | — | US | disclosed |
| EP-1771428-A1 | GUANIDINE DERIVATIVES AND THERAPEUTIC USES THEREOF | MERCK PATENT GmbH (DE) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006010422-A1 | GUANIDINE DERIVATIVES AND THERAPEUTIC USES THEREOF | MERCK PATENT GMBH (DE) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004315-A1 | Guanidine Derivatives and Therapeutic Uses Thereof | GMPS, GUCY1A2, GUCY1A1 | KMT2A 4444/4885MEN1 4419/4885CYP1A2 224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.