Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 6/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15386626 | 1.00 | OPRK1 (0.39) | OPRK1OPRM1OPRD1CYP2D6GPR88 | |
| SCHEMBL434123 | 0.93 | OPRK1 (0.39) | OPRK1OPRM1OPRD1CYP2D6GPR88 | |
| SCHEMBL15385518 | 0.93 | OPRK1 (0.39) | OPRK1OPRM1OPRD1CYP2D6GPR88 | |
| SCHEMBL10083324 | 0.88 | SCN1A (0.39) | OPRK1OPRM1OPRD1CYP2D6GPR88 | |
| SCHEMBL15380713 | 0.88 | OPRK1 (0.40) | OPRK1OPRM1OPRD1CYP2D6GPR88 | |
| SCHEMBL10083360 | 0.88 | OPRK1 (0.40) | OPRK1OPRM1OPRD1CYP2D6GPR88 | |
| SCHEMBL433777 | 0.88 | SCN1A (0.39) | OPRK1OPRM1OPRD1CYP2D6GPR88 | |
| SCHEMBL431742 | 0.87 | ROCK2 (0.44) | OPRK1OPRM1OPRD1GPR88ROCK2 | |
| SCHEMBL15385516 | 0.87 | ROCK2 (0.44) | OPRK1OPRM1OPRD1GPR88ROCK2 | |
| SCHEMBL433167 | 0.86 | OPRK1 (0.42) | OPRK1OPRM1OPRD1CYP2D6GPR88 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012012410-A2 | KAPPA OPIOID RECEPTOR AGONISTS | DR. REDDY'S LABORATORIES LTD. (IN) | 2012-01-26 | — | — | WO | disclosed |
| WO-2012012410-A2 | KAPPA OPIOID RECEPTOR AGONISTS | DR. REDDY'S LABORATORIES LTD. (IN) | 2012-01-26 | — | — | WO | disclosed |