Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 8/20 | 0.71 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.71 |
| ▸ | TSHR | P16473 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NAAA | Q02083 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4310762 | 0.89 | HCRTR1 (0.72) | HCRTR1HCRTR2TSHRLMNAGAA | |
| SCHEMBL4312769 | 0.87 | HCRTR1 (0.68) | HCRTR1HCRTR2TSHRLMNAGAA | |
| SCHEMBL17066796 | 0.85 | HCRTR1 (0.66) | HCRTR1HCRTR2TSHRLMNAGAA | |
| SCHEMBL1672524 | 0.83 | HCRTR1 (1.00) | HCRTR1HCRTR2TSHRLMNAGAA | |
| SCHEMBL4322323 | 0.82 | HCRTR1 (0.67) | HCRTR1HCRTR2TSHRLMNAGAA | |
| SCHEMBL1586374 | 0.78 | HCRTR1 (0.67) | HCRTR1HCRTR2TSHRLMNAGAA | |
| SCHEMBL1671777 | 0.78 | HCRTR1 (0.85) | HCRTR1HCRTR2TSHRLMNAMAPT | |
| SCHEMBL4314484 | 0.77 | HCRTR1 (0.59) | HCRTR1HCRTR2TSHRLMNAGAA | |
| SCHEMBL4243332 | 0.76 | HCRTR1 (0.60) | HCRTR1HCRTR2LMNA | |
| SCHEMBL29784238 | 0.75 | MGLL (0.54) | HCRTR1HCRTR2TSHRLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001485-B1 | DIAZEPAN OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2015-09-09 | — | — | EP | claimed |
| US-20090124603-A1 | Diazepan Orexin Receptor Antagonists | MERCK SHARP & DOHME LLC | 2009-05-14 | — | — | US | claimed |
| EP-2001485-B1 | DIAZEPAN OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2015-09-09 | — | — | EP | disclosed |
| US-20090124603-A1 | Diazepan Orexin Receptor Antagonists | MERCK SHARP & DOHME LLC | 2009-05-14 | — | — | US | disclosed |
| US-20090124603-A1 | Diazepan Orexin Receptor Antagonists | MERCK SHARP & DOHME LLC | 2009-05-14 | — | — | US | disclosed |
| US-20090124603-A1 | Diazepan Orexin Receptor Antagonists | MERCK SHARP & DOHME LLC | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124603-A1 | Diazepan Orexin Receptor Antagonists | HCRTR2, HCRTR1, OXTR | HCRTR1 2/4885HCRTR2 1/4885TSHR 236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.