Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | EPOR | P19235 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | UBE2M | P61081 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.39 |
| ▸ | CTSV | O60911 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4325900 | 1.00 | LTA4H (0.46) | LTA4HMAPK1EPORPDK1PDK2 | |
| SCHEMBL4322601 | 0.89 | LTA4H (0.52) | LTA4HKMT2AMEN1 | |
| SCHEMBL4322605 | 0.89 | LTA4H (0.52) | LTA4HKMT2AMEN1 | |
| SCHEMBL4315147 | 0.85 | PDK1 (0.46) | LTA4HMAPK1PDK1PDK2PDK3 | |
| SCHEMBL4315149 | 0.85 | PDK1 (0.46) | LTA4HMAPK1PDK1PDK2PDK3 | |
| SCHEMBL5168781 | 0.83 | EPOR (0.45) | LTA4HMAPK1EPORSPHK2KMT2A | |
| SCHEMBL4316758 | 0.77 | MAOB (0.38) | LTA4HKMT2AMEN1MAOB | |
| SCHEMBL4316756 | 0.77 | MAOB (0.38) | LTA4HKMT2AMEN1MAOB | |
| SCHEMBL4319604 | 0.77 | LTA4H (0.55) | LTA4HLMNAKMT2AMEN1 | |
| SCHEMBL4319602 | 0.77 | LTA4H (0.55) | LTA4HLMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582656-B2 | Guanidine derivatives and therapeutic uses thereof | MERCK PATENT GESELLSCHAFT (DE) | 2009-09-01 | — | — | US | claimed |
| EP-1771428-A1 | GUANIDINE DERIVATIVES AND THERAPEUTIC USES THEREOF | MERCK PATENT GmbH (DE) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006010422-A1 | GUANIDINE DERIVATIVES AND THERAPEUTIC USES THEREOF | MERCK PATENT GMBH (DE) | 2006-02-02 | — | — | WO | disclosed |