Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.58 |
| ▸ | ACR | P10323 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 3/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14062435 | 0.87 | MAPT (0.83) | MAPTTDP1L3MBTL1PRSS1ACR | |
| SCHEMBL2396251 | 0.87 | MAPT (0.83) | MAPTTDP1L3MBTL1PRSS1ACR | |
| SCHEMBL919272 | 0.85 | GSK3B (0.66) | MAPTTDP1ALDH1A1LMNAALOX15 | |
| SCHEMBL2395069 | 0.82 | MAPT (0.75) | MAPTTDP1L3MBTL1PRSS1ACR | |
| SCHEMBL14062417 | 0.82 | MAPT (0.75) | MAPTTDP1L3MBTL1PRSS1ACR | |
| SCHEMBL14062466 | 0.82 | MAPT (0.75) | MAPTTDP1L3MBTL1PRSS1ACR | |
| SCHEMBL16775315 | 0.81 | MAPT (0.73) | MAPTTDP1L3MBTL1PRSS1ACR | |
| SCHEMBL21266478 | 0.81 | MAPT (0.73) | MAPTTDP1L3MBTL1PRSS1ACR | |
| SCHEMBL4328066 | 0.81 | MAPT (0.73) | MAPTTDP1L3MBTL1PRSS1ACR | |
| SCHEMBL29004336 | 0.81 | MAPT (0.78) | MAPTTDP1L3MBTL1PRSS1ACR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009146013-A1 | MYOSIN LIGHT CHAIN PHOSPHATASE INHIBITORS | GEORGETOWN UNIVERSITY (US) | 2009-12-03 | — | — | WO | disclosed |