Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.48 |
| ▸ | CTSG | P08311 | 4/20 | 0.48 |
| ▸ | CTRB1 | P17538 | 4/20 | 0.48 |
| ▸ | CMA1 | P23946 | 4/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4332252 | 0.86 | LMNA (0.47) | NPC1RAB9ASLC6A2SLC6A3PRSS1 | |
| SCHEMBL17644177 | 0.84 | SLC6A2 (0.50) | NPC1RAB9ASLC6A2SLC6A3PRSS1 | |
| SCHEMBL29421043 | 0.83 | SLC6A2 (0.49) | NPC1RAB9ASLC6A2SLC6A3PRSS1 | |
| Hydrochloric Acid SCHEMBL22614751 | 0.83 | SLC6A2 (0.49) | NPC1RAB9ASLC6A2SLC6A3PRSS1 | |
| SCHEMBL29360210 | 0.81 | SLC6A2 (0.51) | NPC1RAB9ASLC6A2SLC6A3PRSS1 | |
| SCHEMBL836149 | 0.81 | CTSK (0.55) | PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL836148 | 0.81 | CTSK (0.55) | PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL4177126 | 0.80 | MDM2 (0.44) | NPC1RAB9APGRADRA2AADRA2B | |
| SCHEMBL3316473 | 0.80 | MDM2 (0.44) | NPC1RAB9APGRADRA2AADRA2B | |
| SCHEMBL16101837 | 0.79 | CYP3A4 (0.39) | NPC1RAB9APGRADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102169-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | AstraZeneca AB (SE) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008076048-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |