⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005718 | 0.97 | HIF1A (0.35) | — | |
| SCHEMBL431279 | 0.67 | HIF1A (0.33) | — | |
| SCHEMBL16559 | 0.65 | — | — | |
| SCHEMBL27415328 | 0.65 | ALPL (0.36) | — | |
| SCHEMBL17120 | 0.65 | — | — | |
| SCHEMBL27810538 | 0.65 | — | — | |
| SCHEMBL28206655 | 0.65 | — | — | |
| SCHEMBL16558 | 0.65 | — | — | |
| SCHEMBL23375976 | 0.62 | — | — | |
| SCHEMBL294662 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117069732-B | Preparation method of benzo [ c ] phenanthridine natural product and derivative thereof | 沈阳药科大学 | 2024-04-26 | — | — | CN | claimed |
| CN-117069732-A | Preparation method of benzo [ c ] phenanthridine natural product and derivative thereof | 沈阳药科大学 | 2023-11-17 | — | — | CN | claimed |
| CN-110418784-A | Be used to prepare 3,7- it is bis--method of (dimethylamino)-phenthazine -5- chloride or bromide | MIKROCHEM SPOL S R O | 2019-11-05 | — | — | CN | claimed |
| CN-107857737-A | A kind of preparation technology of the chloropyrazine of 2 bromine 3,5,6 3 | 贵州大学 | 2018-03-30 | — | — | CN | claimed |
| CN-118955466-A | Method for preparing unsaturated carbonyl compound by carbonyl-alkyne double decomposition reaction | 兰州大学 | 2024-11-15 | — | — | CN | disclosed |
| CN-116444477-A | Preparation method and application of bromopiperonyl carboxylic acid | 宁波九胜创新医药科技有限公司 | 2023-07-18 | — | — | CN | disclosed |
| CN-116348474-A | Azoline saccharide compound, preparation method and application thereof | 中国科学院上海药物研究所 | 2023-06-27 | — | — | CN | disclosed |
| CN-109153643-A | Substituted indole MCL-1 inhibitors | 范德比尔特大学 | 2019-01-04 | — | — | CN | disclosed |
| CN-107857737-A | A kind of preparation technology of the chloropyrazine of 2 bromine 3,5,6 3 | 贵州大学 | 2018-03-30 | — | — | CN | disclosed |
| CN-105555780-B | SYK inhibitors | 吉利德科学公司 | 2018-01-23 | — | — | CN | disclosed |
| CN-104447606-B | The synthetic method of a kind of 2-bromo-1,3-piperazine compound of carbonyl-4-alkene-5-and application | 中国科学院化学研究所 | 2016-06-15 | — | — | CN | disclosed |
| CN-104447606-B | The synthetic method of a kind of 2-bromo-1,3-piperazine compound of carbonyl-4-alkene-5-and application | 中国科学院化学研究所 | 2016-06-15 | — | — | CN | disclosed |
| CN-102639500-A | Tricyclic compound, preparation method and pharmaceutical use thereof | SHANGHAI HENGRUI PHARM CO LTD | 2012-08-15 | — | — | CN | disclosed |
| US-7569690-B2 | Process for producing oxycarbonyl-substituted piperazine derivative | TORAY FINE CHEMICALS CO., LTD. (JP) | 2009-08-04 | — | — | US | disclosed |
| CN-101479256-A | New pyridine analogues | ASTRAZENECA AB (SE) | 2009-07-08 | — | — | CN | disclosed |
| CN-100360510-C | Process for producing oxycarbonyl-substituted piperazine derivative | TORAY FINECHEMICALS CO LTD (JP) | 2008-01-09 | — | — | CN | disclosed |
| US-20060161003-A1 | Process for producing oxycarbonyl-substituted piperazine derivative | TORAY FINE CHEMICALS CO., LTD. (JP) | 2006-07-20 | — | — | US | disclosed |
| CN-1681797-A | Process for producing oxycarbonyl-substituted piperazine derivative | TORAY FINECHEMICALS CO LTD (JP) | 2005-10-12 | — | — | CN | disclosed |
| EP-1548010-A1 | PROCESS FOR PRODUCING OXYCARBONYL-SUBSTITUTED PIPERAZINE DERIVATIVE | Toray Fine Chemicals Co., Ltd. (JP) | 2005-06-29 | — | — | EP | disclosed |
| CN-1418197-A | Piperidine and piperazine substituted N-hydroxycarboxamides as metalloproteinase inhibitors | ASTRAZENECA AB (SE) | 2003-05-14 | — | — | CN | disclosed |