SCHEMBL4329044

SCHEMBL4329044

CC(C)c1ccc(N(C)C(=O)C2c3ccccc3C(=O)N2C2CCN(C(=O)O)CC2)cn1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 2/20 0.40
MEN1 O00255 1/20 0.40
GAA P10253 1/20 0.40
KMT2A Q03164 1/20 0.40
ALDH1A1 P00352 7/20 0.39
TSHR P16473 5/20 0.38
MAPT P10636 3/20 0.38
ALOX15 P16050 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.36
FPR1 P21462 2/20 0.35
CYP3A4 P08684 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
KCNH2 Q12809 1/20 0.35
SCN5A Q14524 1/20 0.35
SCN9A Q15858 1/20 0.35
HPGD P15428 2/20 0.35
HSD17B10 Q99714 2/20 0.35
L3MBTL1 Q9Y468 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4334944 0.73 SCN9A (0.43) KCNH2SCN5ASCN9AL3MBTL1MAPK1
SCHEMBL4331795 0.73 SMN1; SMN2 (0.35) ALDH1A1TSHRSMN1; SMN2FPR1CYP3A4
SCHEMBL13579065 0.71 SCN9A (0.54) ALDH1A1TSHRSMN1; SMN2FPR1CYP3A4
SCHEMBL4321206 0.69 SCN9A (0.41) KCNH2SCN5ASCN9A
SCHEMBL18291568 0.64 MLNR (0.35) MEN1KMT2A
SCHEMBL4332531 0.60 KDM4E (0.54) ALDH1A1TSHRSMN1; SMN2KDM4EHTT
SCHEMBL4318494 0.60 SCN9A (0.57) NPSR1MEN1GAAKMT2AALDH1A1
SCHEMBL4327202 0.60 SCN9A (0.54) MEN1KMT2AALDH1A1TSHRMAPT
SCHEMBL13577812 0.58 NPC1 (0.61) NPSR1MEN1GAAKMT2AALDH1A1
SCHEMBL4317569 0.58 SCN9A (0.56) NPSR1MEN1GAAKMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009145720-A1 ISOINDOLINE DERIVATIVES COMPRISING ADDITIONAL HETEROCYCLIC GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS ASTRAZENECA AB (SE) 2009-12-03 WO claimed
WO-2009145720-A1 ISOINDOLINE DERIVATIVES COMPRISING ADDITIONAL HETEROCYCLIC GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS ASTRAZENECA AB (SE) 2009-12-03 WO disclosed