Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 15/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4321206 | 0.90 | SCN9A (0.41) | SCN9AKCNH2SCN5AGPR119 | |
| SCHEMBL4334938 | 0.80 | SCN9A (0.62) | SCN9AKCNH2SCN5A | |
| SCHEMBL4331795 | 0.74 | SMN1; SMN2 (0.35) | SCN9AKCNH2SCN5A | |
| SCHEMBL4329044 | 0.73 | NPSR1 (0.40) | SCN9AKCNH2SCN5AL3MBTL1MAPK1 | |
| SCHEMBL13579104 | 0.72 | SCN9A (0.70) | SCN9AKCNH2SCN5A | |
| SCHEMBL4322993 | 0.71 | SCN9A (0.58) | SCN9AKCNH2SCN5A | |
| SCHEMBL4326647 | 0.69 | SCN9A (0.64) | SCN9AKCNH2SCN5A | |
| SCHEMBL4457879 | 0.67 | SCN9A (0.68) | SCN9AKCNH2SCN5A | |
| SCHEMBL13579101 | 0.67 | SCN9A (0.69) | SCN9AKCNH2SCN5A | |
| SCHEMBL4329573 | 0.64 | SCN9A (0.66) | SCN9AKCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009145720-A1 | ISOINDOLINE DERIVATIVES COMPRISING ADDITIONAL HETEROCYCLIC GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS | ASTRAZENECA AB (SE) | 2009-12-03 | — | — | WO | claimed |
| WO-2009145720-A1 | ISOINDOLINE DERIVATIVES COMPRISING ADDITIONAL HETEROCYCLIC GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS | ASTRAZENECA AB (SE) | 2009-12-03 | — | — | WO | disclosed |