Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.62 |
| ▸ | HTR2A | P28223 | 3/20 | 0.53 |
| ▸ | HTR6 | P50406 | 6/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27844923 | 0.81 | MAPT (0.44) | HTR2CPRMT5ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL20656048 | 0.80 | NR3C1 (0.47) | PRMT5ALDH1A1SMN1; SMN2MAPTNR3C1 | |
| SCHEMBL23956102 | 0.77 | HTR2C (0.68) | HTR2CHTR2AHTR6HTR1D | |
| SCHEMBL337413 | 0.77 | HTR2C (0.68) | HTR2CHTR2AHTR6HTR1D | |
| SCHEMBL847974 | 0.77 | HTR2C (0.68) | HTR2CHTR2AHTR6HTR1D | |
| SCHEMBL23927902 | 0.75 | HTR2C (0.64) | HTR2CHTR2AHTR6PRMT5ALDH1A1 | |
| SCHEMBL506644 | 0.74 | IMPDH2 (0.59) | HTR6PRMT5ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16234643 | 0.73 | STAT3 (0.50) | PRMT5ALDH1A1SMN1; SMN2MAPTNR3C1 | |
| SCHEMBL418623 | 0.73 | STAT3 (0.50) | PRMT5ALDH1A1SMN1; SMN2MAPTNR3C1 | |
| SCHEMBL4327390 | 0.73 | PRMT5 (0.48) | PRMT5ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090311217-A1 | 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090311217-A1 | 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | MTOR, RICTOR, PDPK1 | HTR2C 413/4885HTR2A 768/4885HTR6 581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.