Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.57 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.54 |
| ▸ | KLK7 | P49862 | 1/20 | 0.53 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29465523 | 0.93 | FOLH1 (0.67) | FOLH1MAPTKLK7KLK5ABCB1 | |
| SCHEMBL18161563 | 0.93 | FOLH1 (0.67) | FOLH1MAPTKLK7KLK5ABCB1 | |
| SCHEMBL4330583 | 0.93 | FOLH1 (0.67) | FOLH1MAPTKLK7KLK5ABCB1 | |
| SCHEMBL563808 | 0.93 | FOLH1 (0.67) | FOLH1MAPTKLK7KLK5ABCB1 | |
| SCHEMBL29679325 | 0.93 | FOLH1 (0.67) | FOLH1MAPTKLK7KLK5ABCB1 | |
| SCHEMBL23849707 | 0.91 | FOLH1 (0.55) | FOLH1SIRT2SIRT1MAPTSIRT3 | |
| SCHEMBL19065207 | 0.91 | FOLH1 (0.55) | FOLH1SIRT2SIRT1MAPTSIRT3 | |
| SCHEMBL30485723 | 0.90 | FOLH1 (0.62) | FOLH1MAPTKLK7KLK5ABCB1 | |
| SCHEMBL25963725 | 0.90 | FOLH1 (0.62) | FOLH1MAPTKLK7KLK5ABCB1 | |
| SCHEMBL31318079 | 0.90 | FOLH1 (0.62) | FOLH1MAPTKLK7KLK5ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097111-A2 | HETERODIMERS OF GLUTAMIC ACID | Molecular Insight Pharmaceuticals, Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008058192-A2 | HETERODIMERS OF GLUTAMIC ACID | MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) | 2008-05-15 | — | — | WO | disclosed |