Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 9/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4318553 | 0.85 | MTNR1A (0.38) | MTNR1AMTNR1BHSD17B2ALOX15HSD17B1 | |
| SCHEMBL4318558 | 0.85 | MTNR1A (0.38) | MTNR1AMTNR1BHSD17B2ALOX15HSD17B1 | |
| SCHEMBL4318019 | 0.72 | MTNR1A (0.39) | MTNR1AMTNR1BHSD17B2ALOX15ALDH1A1 | |
| SCHEMBL4318013 | 0.72 | MTNR1A (0.39) | MTNR1AMTNR1BHSD17B2ALOX15ALDH1A1 | |
| SCHEMBL28188568 | 0.71 | MTNR1A (0.49) | MTNR1AMTNR1B | |
| SCHEMBL8812902 | 0.71 | MTNR1A (0.51) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL8428661 | 0.69 | MTNR1A (0.46) | MTNR1AMTNR1BHSD17B2ALOX15ALDH1A1 | |
| SCHEMBL20264517 | 0.69 | HSD17B2 (0.61) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL11437844 | 0.68 | MTNR1A (0.43) | MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL11433747 | 0.68 | KMT2A (0.46) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102169-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | AstraZeneca AB (SE) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008076048-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |