Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 12/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 12/20 | 0.51 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8428661 | 0.82 | MTNR1A (0.46) | MTNR1AMTNR1BHSD17B2CES2CES1 | |
| SCHEMBL5254203 | 0.82 | HSD17B2 (0.46) | MTNR1AMTNR1BHSD17B2CES2CES1 | |
| SCHEMBL6136382 | 0.80 | MTNR1A (0.51) | MTNR1AMTNR1BHSD17B2CES2CES1 | |
| SCHEMBL26624252 | 0.80 | MTNR1B (0.56) | MTNR1AMTNR1BHSD17B2CES2CES1 | |
| SCHEMBL6511331 | 0.80 | TRPM8 (0.52) | MTNR1AMTNR1BCES2CES1PARP1 | |
| SCHEMBL11027897 | 0.78 | HSD17B2 (0.61) | MTNR1AMTNR1BHSD17B2CES2CES1 | |
| SCHEMBL1548437 | 0.78 | MTNR1B (0.55) | MTNR1AMTNR1BHSD17B2CES2CES1 | |
| SCHEMBL5897694 | 0.78 | MTNR1A (0.44) | MTNR1AMTNR1BHSD17B2 | |
| SCHEMBL27784974 | 0.77 | ALDH1A1 (0.47) | NPC1 | |
| SCHEMBL27662593 | 0.77 | MTNR1A (0.54) | MTNR1AMTNR1BHSD17B2CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755384-A1 | CCK OR GASTRIN MODULATING 1,5 BENZODIAZEPINES DERIVATIVES | GLAXO WELLCOME INC. (US) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028391-A1 | CCK OR GASTRIN MODULATING 1,5 BENZODIAZEPINES DERIVATIVES | GLAXO WELLCOME INC. (US) | 1995-10-26 | — | — | WO | disclosed |