Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 7/20 | 0.73 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.73 |
| ▸ | VDR | P11473 | 2/20 | 0.73 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.63 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.63 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.59 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.59 |
| ▸ | SLC10A2 | Q12908 | 2/20 | 0.59 |
| ▸ | SLC10A1 | Q14973 | 2/20 | 0.59 |
| ▸ | CASP7 | P55210 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | BLM | P54132 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | MDM4 | O15151 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL977813 | 0.90 | VDR (0.69) | GPBAR1EPHA2VDRABCC4NR1H4 | |
| SCHEMBL15156945 | 0.90 | VDR (0.69) | GPBAR1EPHA2VDRABCC4NR1H4 | |
| SCHEMBL5154446 | 0.90 | VDR (0.69) | GPBAR1EPHA2VDRABCC4NR1H4 | |
| SCHEMBL7146262 | 0.87 | GPBAR1 (0.70) | GPBAR1EPHA2VDRABCC4ABCC1 | |
| SCHEMBL22572509 | 0.87 | GPBAR1 (0.62) | GPBAR1EPHA2VDRNR1H4CASP7 | |
| SCHEMBL6698178 | 0.86 | GPBAR1 (0.74) | GPBAR1EPHA2VDRABCC4NR1H4 | |
| SCHEMBL5667769 | 0.86 | GPBAR1 (0.74) | GPBAR1EPHA2VDRABCC4NR1H4 | |
| SCHEMBL6064363 | 0.86 | GPBAR1 (0.61) | GPBAR1EPHA2VDRNR1H4CASP7 | |
| SCHEMBL17501642 | 0.85 | GPBAR1 (0.73) | GPBAR1EPHA2VDRABCC4ABCC1 | |
| Lithoglycocholate SCHEMBL24001379 | 0.84 | GPBAR1 (1.00) | GPBAR1EPHA2VDRNR1H4ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423829-A1 | METHOD FOR DETERMININGIN VITRO | Clayton Pharmaceuticals LLC (US) | 2019-01-09 | — | — | EP | claimed |
| WO-2018204894-A1 | METHOD FOR DETERMINING IN VITRO BIOEQUIVALENCE OF A SUCRALFATE SUSPENSION SAMPLE TO A SUCRALFATE SUSPENSION REFERENCE LISTED DRUG (RLD) | CLAYTON PHARMACEUTICALS LLC (US) | 2018-11-08 | — | — | WO | claimed |
| US-9989519-B1 | Method for determining in vitro bioequivalence of a sucralfate suspension sample to a sucralfate suspension reference listed drug (RLD) | Clayton Pharmaceuticals, LLC (US) | 2018-06-05 | — | — | US | claimed |
| EP-3423829-A1 | METHOD FOR DETERMININGIN VITRO | Clayton Pharmaceuticals LLC (US) | 2019-01-09 | — | — | EP | disclosed |
| WO-2018204894-A1 | METHOD FOR DETERMINING IN VITRO BIOEQUIVALENCE OF A SUCRALFATE SUSPENSION SAMPLE TO A SUCRALFATE SUSPENSION REFERENCE LISTED DRUG (RLD) | CLAYTON PHARMACEUTICALS LLC (US) | 2018-11-08 | — | — | WO | disclosed |
| EP-1427289-B1 | PULSATILE RELEASE COMPOSITIONS AND METHODS FOR ENHANCED GASTROINTESTINAL DRUG ABSORPTION | IONIS PHARMACEUTICALS INC (US) | 2017-05-10 | — | — | EP | disclosed |
| WO-2009052186-A1 | METABOLOMICS-BASED IDENTIFICATION OF DISEASE-CAUSING AGENTS | GEORGIA TECH RESEARCH CORPORATION (US) | 2009-04-23 | — | — | WO | disclosed |
| EP-1427289-A4 | PULSATILE RELEASE COMPOSITIONS AND METHODS FOR ENHANCED GASTROINTESTINAL DRUG ABSORPTION | ISIS PHARMACEUTICALS INC (US) | 2006-06-28 | — | — | EP | disclosed |
| US-20050196443-A1 | Pulsatile release compositions and methods for enhanced intestinal drug absorption | ISIS PHARMACEUTICALS, INC. (US) | 2005-09-08 | — | — | US | disclosed |
| EP-1427289-A2 | PULSATILE RELEASE COMPOSITIONS AND METHODS FOR ENHANCED GASTROINTESTINAL DRUG ABSORPTION | ISIS Pharmaceuticals, Inc. (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003017940-A2 | PULSATILE RELEASE COMPOSITIONS AND METHODS FOR ENHANCED GASTROINTESTINAL DRUG ABSORPTION | ISIS PHARMACEUTICALS, INC. (US) | 2003-03-06 | — | — | WO | disclosed |