SCHEMBL433143

SCHEMBL433143

C=COC(=O)/C(C)=C\C

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL433144 1.00
SCHEMBL19745993 1.00
SCHEMBL11236699 0.85 ALDH1A1 (0.58)
SCHEMBL9619963 0.82
SCHEMBL10440582 0.81 ALDH1A1 (0.31)
SCHEMBL1326400 0.80 ALDH1A1 (0.33)
SCHEMBL11854997 0.80
SCHEMBL28364394 0.80 ALDH1A1 (0.33)
SCHEMBL10975196 0.78 ALDH1A1 (0.32)
SCHEMBL29143207 0.78 LMNA (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9676698-B2 Method of producing ingenol-3-angelate LEO LABORATORIES LIMITED (IE) 2017-06-13 US claimed
EP-3640236-A1 A METHOD OF PRODUCING INGENOL-3-ANGELATE LEO LABORATORIES LIMITED (IE) 2020-04-22 EP disclosed
EP-2595948-B1 A METHOD OF PRODUCING INGENOL-3-ANGELATE LEO LABORATORIES LTD (IE) 2019-09-04 EP disclosed
EP-2872477-B1 PROCESS FOR THE PREPARATION OF INGENOL-3-ANGELATE FROM 20-DEOXY-INGENOL LEO LABORATORIES LTD (IE) 2018-09-05 EP disclosed
US-9676698-B2 Method of producing ingenol-3-angelate LEO LABORATORIES LIMITED (IE) 2017-06-13 US disclosed
US-9624157-B2 Process for the preparation of ingenol-3-angelate from 20-deoxy-ingenol LEO LABORATORIES LIMITED (IE) 2017-04-18 US disclosed
US-20160280627-A1 METHOD OF PRODUCING INGENOL-3-ANGELATE LEO LABORATORIES LIMITED (IE) 2016-09-29 US disclosed
US-9416084-B2 Method of producing ingenol-3-angelate LEO LABORATORIES LIMITED (IE) 2016-08-16 US disclosed
US-9404131-B2 Process for the preparation of ingenol-3-angelate LEO LABORATORIES LIMITED (IE) 2016-08-02 US disclosed
US-9404131-B2 Process for the preparation of ingenol-3-angelate LEO LABORATORIES LIMITED (IE) 2016-08-02 US disclosed
EP-2872477-A1 PROCESS FOR THE PREPARATION OF INGENOL-3-ANGELATE FROM 20-DEOXY-INGENOL Leo Laboratories Limited (IE) 2015-05-20 EP disclosed
CN-104470888-A Process for the preparation of ingenol-3-angelate from 20-deoxy-ingenol LEO LAB LTD 2015-03-25 CN disclosed
US-20150024443-A1 PROCESS FOR THE PREPARATION OF INGENOL-3-ANGELATE LEO LABORATORIES LIMITED (IE) 2015-01-22 US disclosed
US-20150024443-A1 PROCESS FOR THE PREPARATION OF INGENOL-3-ANGELATE LEO LABORATORIES LIMITED (IE) 2015-01-22 US disclosed
US-8901356-B2 Method of producing ingenol-3-angelate LEO LABORATORIES LIMITED (IE) 2014-12-02 US disclosed
WO-2014012836-A1 PROCESS FOR THE PREPARATION OF INGENOL-3-ANGELATE FROM 20-DEOXY-INGENOL LEO LABORATORIES LIMITED (IE) 2014-01-23 WO disclosed
WO-2013110753-A1 PROCESS FOR THE PREPARATION OF INGENOL-3-ANGELATE LEO PHARMA A/S (DK) 2013-08-01 WO disclosed
US-20130177952-A1 METHOD OF PRODUCING INGENOL-3-ANGELATE Hogberg, Thomas (DK) 2013-07-11 US disclosed
EP-2595948-A1 A METHOD OF PRODUCING INGENOL-3-ANGELATE LEO LABORATORIES LIMITED (IE) 2013-05-29 EP disclosed
WO-2012010172-A1 A METHOD OF PRODUCING INGENOL-3-ANGELATE LEO PHARMA A/S (DK) 2012-01-26 WO disclosed