Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8733990 | 0.82 | CYP1A2 (0.42) | TSHRCYP2D6CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL28790233 | 0.82 | TSHR (0.42) | TSHRCYP2D6CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL3364003 | 0.79 | CYP2D6 (0.42) | TSHRCYP2D6CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL28399440 | 0.76 | TSHR (0.46) | TSHRCYP2D6CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL8089565 | 0.75 | TSHR (0.50) | TSHRCYP2D6CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL6470482 | 0.75 | CYP2C19 (0.55) | CYP2D6CYP1A2CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL29608887 | 0.75 | CYP2D6 (0.48) | CYP2D6CYP1A2CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL28175240 | 0.75 | TSHR (0.50) | TSHRCYP2D6CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL9723670 | 0.75 | CYP2D6 (0.48) | CYP2D6CYP1A2CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL3959121 | 0.73 | CYP2D6 (0.47) | CYP2D6CYP1A2CYP2C19ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544835-B2 | Carboxylic acid derivative and salt thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-09 | — | — | US | disclosed |
| US-20040102634-A1 | Carboxylic acid derivative and salt thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2004-05-27 | — | — | US | disclosed |
| EP-1380562-A1 | CARBOXYLIC ACID DERIVATIVE AND SALT THEREOF | Eisai Co., Ltd. (JP) | 2004-01-14 | — | — | EP | disclosed |
| CN-1236612-A | Methods and compositions for protecting animals and humans against attack and infestation by arthropod and helminth parasites | AMERICAN CYANAMID CO (US) | 1999-12-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102634-A1 | Carboxylic acid derivative and salt thereof | GPR119, IRS1, SLC5A1 | TSHR 532/4885CYP2D6 331/4885CYP1A2 1508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.