Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.55 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11241976 | 0.91 | CHRNB2 (0.56) | NPC1CHRNB2CHRNA4ALDH1A1KMT2A | |
| SCHEMBL6482501 | 0.87 | TSHR (0.57) | NPC1CHRNB2CHRNA4ALDH1A1KMT2A | |
| SCHEMBL6482493 | 0.87 | TSHR (0.57) | NPC1CHRNB2CHRNA4ALDH1A1KMT2A | |
| SCHEMBL773149 | 0.86 | NPC1 (0.53) | NPC1CHRNB2CHRNA4ALDH1A1KMT2A | |
| SCHEMBL7870934 | 0.84 | CHRNB2 (0.57) | NPC1CHRNB2CHRNA4ALDH1A1KMT2A | |
| SCHEMBL7430588 | 0.83 | NPC1 (0.52) | NPC1CHRNB2CHRNA4ALDH1A1KMT2A | |
| SCHEMBL15060886 | 0.82 | ALDH1A1 (0.70) | ALDH1A1KMT2AMEN1MAPTGAA | |
| SCHEMBL1496497 | 0.82 | ALDH1A1 (0.70) | ALDH1A1KMT2AMEN1MAPTGAA | |
| SCHEMBL4631758 | 0.82 | CHRNB2 (0.60) | CHRNB2CHRNA4ALDH1A1KMT2AMEN1 | |
| SCHEMBL15060972 | 0.82 | ALDH1A1 (0.70) | ALDH1A1KMT2AMEN1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102169-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | AstraZeneca AB (SE) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008076048-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |