Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.62 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10420079 | 0.93 | CHRNB2 (0.60) | CHRNB2CHRNA4HPGDLMNAMAOB | |
| SCHEMBL13251266 | 0.88 | CHRNB2 (0.65) | CHRNB2CHRNA4HPGDLMNAMAOB | |
| Methane SCHEMBL27262738 | 0.87 | CHRNB2 (0.63) | CHRNB2CHRNA4HPGDLMNAMAOB | |
| SCHEMBL7870934 | 0.84 | CHRNB2 (0.57) | CHRNB2CHRNA4HPGDLMNAMAOB | |
| SCHEMBL15498199 | 0.83 | CHRNB2 (0.73) | CHRNB2CHRNA4HPGDLMNAMAOB | |
| SCHEMBL12746091 | 0.83 | CHRNB2 (0.62) | CHRNB2CHRNA4HPGDLMNAMAOB | |
| SCHEMBL31520919 | 0.83 | CHRNB2 (0.62) | CHRNB2CHRNA4HPGDLMNAMAOB | |
| SCHEMBL6138558 | 0.82 | MAPT (0.57) | ALDH1A1MAPT | |
| SCHEMBL363891 | 0.81 | CHRNB2 (0.59) | CHRNB2CHRNA4HPGDLMNAMAOB | |
| SCHEMBL2374109 | 0.80 | CHRNB2 (0.70) | CHRNB2CHRNA4HPGDLMNAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102169-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | AstraZeneca AB (SE) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008076048-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |