Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.59 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31520919 | 0.86 | CHRNB2 (0.62) | CHRNB2CHRNA4HPGDMAPTALDH1A1 | |
| SCHEMBL13251266 | 0.83 | CHRNB2 (0.65) | CHRNB2CHRNA4HPGDMAPTALDH1A1 | |
| Methane SCHEMBL27262738 | 0.82 | CHRNB2 (0.63) | CHRNB2CHRNA4HPGDMAPTALDH1A1 | |
| SCHEMBL15498199 | 0.81 | CHRNB2 (0.73) | CHRNB2CHRNA4HPGDMAPTALDH1A1 | |
| SCHEMBL4331856 | 0.81 | CHRNB2 (0.62) | CHRNB2CHRNA4HPGDMAPTALDH1A1 | |
| SCHEMBL30833154 | 0.80 | CHRNB2 (0.68) | CHRNB2CHRNA4HPGDMAPTALDH1A1 | |
| SCHEMBL3460244 | 0.80 | CHRNB2 (0.68) | CHRNB2CHRNA4HPGDMAPTALDH1A1 | |
| SCHEMBL15716420 | 0.79 | TSHR (0.55) | MAPTALDH1A1LMNAMAOBTSHR | |
| SCHEMBL2063354 | 0.79 | CHRNB2 (0.67) | CHRNB2CHRNA4HPGDMAPTALDH1A1 | |
| SCHEMBL2374109 | 0.78 | CHRNB2 (0.70) | CHRNB2CHRNA4HPGDMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593457-A1 | PYRAZOLO [1, 5A]PYRIMIDINE AND THIENO [3, 2B]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007375-A1 | PYRAZOLO [1, 5A] PYRIMIDINE AND THIENO [3, 2B] PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |