Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.46 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.46 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.46 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4313499 | 0.91 | KDM4E (0.47) | CALM1ALOX5ALOX15LDHAPLAAT3 | |
| SCHEMBL28463183 | 0.88 | KIF11 (0.55) | CALM1ALOX5F2RL1ALDH1A1LDHA | |
| SCHEMBL2926805 | 0.88 | KIF11 (0.55) | CALM1ALOX5F2RL1ALDH1A1LDHA | |
| SCHEMBL1238414 | 0.88 | KIF11 (0.55) | CALM1ALOX5F2RL1ALDH1A1LDHA | |
| SCHEMBL10419544 | 0.83 | KIF11 (0.53) | CALM1ALOX5F2RL1ALDH1A1IGF1R | |
| SCHEMBL28463907 | 0.83 | KIF11 (0.53) | CALM1ALOX5F2RL1ALDH1A1IGF1R | |
| SCHEMBL28463903 | 0.83 | KIF11 (0.53) | CALM1ALOX5F2RL1ALDH1A1IGF1R | |
| SCHEMBL10420495 | 0.82 | KIF11 (0.52) | CALM1ALOX5F2RL1IGF1RALOX15 | |
| SCHEMBL28467284 | 0.82 | KIF11 (0.52) | CALM1ALOX5F2RL1IGF1RALOX15 | |
| SCHEMBL28469542 | 0.82 | KIF11 (0.52) | CALM1ALOX5F2RL1IGF1RALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009138378-A1 | 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ARWAY DISEASES | NOVARTIS AG (CH) | 2009-11-19 | — | — | WO | claimed |
| US-8664228-B2 | 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid derivatives and their use as epithelial sodium channel blockers for the treatment of airway diseases | NOVARTIS AG (CH) | 2014-03-04 | — | — | US | disclosed |
| WO-2009138378-A1 | 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ARWAY DISEASES | NOVARTIS AG (CH) | 2009-11-19 | — | — | WO | disclosed |