Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.43 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.43 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.43 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4332341 | 0.91 | CALM1 (0.51) | ALOX15LDHAALOX5CALM1PLAAT3 | |
| Trifluoroacetic Acid SCHEMBL4313504 | 0.85 | ALOX15 (0.47) | KDM4EALOX15TDP1LDHAALOX5 | |
| SCHEMBL28463183 | 0.82 | KIF11 (0.55) | LDHAALOX5CALM1PLAAT3PLAAT5 | |
| SCHEMBL1238414 | 0.82 | KIF11 (0.55) | LDHAALOX5CALM1PLAAT3PLAAT5 | |
| SCHEMBL2926805 | 0.82 | KIF11 (0.55) | LDHAALOX5CALM1PLAAT3PLAAT5 | |
| Trifluoroacetic Acid SCHEMBL7422241 | 0.79 | AOC3 (0.44) | KDM4EALOX15TDP1LDHAALOX5 | |
| SCHEMBL28463903 | 0.78 | KIF11 (0.53) | ALOX15LDHAALOX5CALM1PLAAT3 | |
| SCHEMBL28463907 | 0.78 | KIF11 (0.53) | ALOX15LDHAALOX5CALM1PLAAT3 | |
| SCHEMBL10419544 | 0.78 | KIF11 (0.53) | ALOX15LDHAALOX5CALM1PLAAT3 | |
| SCHEMBL10420495 | 0.77 | KIF11 (0.52) | ALOX15TDP1LDHAALOX5CALM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8664228-B2 | 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid derivatives and their use as epithelial sodium channel blockers for the treatment of airway diseases | NOVARTIS AG (CH) | 2014-03-04 | — | — | US | disclosed |
| EP-2285785-B1 | 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ARWAY DISEASES | NOVARTIS AG (CH) | 2012-09-05 | — | — | EP | disclosed |
| WO-2009138378-A1 | 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ARWAY DISEASES | NOVARTIS AG (CH) | 2009-11-19 | — | — | WO | disclosed |