Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | IDH1 | O75874 | 1/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21480310 | 0.86 | ALDH1A1 (0.61) | ALDH1A1KMT2AMEN1LMNAMAPT | |
| SCHEMBL21695331 | 0.83 | ALDH1A1 (0.58) | ALDH1A1KMT2AMEN1LMNAMAPT | |
| SCHEMBL13055402 | 0.83 | CYP17A1 (0.59) | ALDH1A1SMN1; SMN2CYP17A1GAAPSMB8 | |
| SCHEMBL13264260 | 0.83 | CYP17A1 (0.56) | KMT2AMEN1LMNAMAPTHTT | |
| SCHEMBL26790793 | 0.82 | CYP17A1 (0.45) | ALDH1A1KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL29131710 | 0.82 | HPGD (0.59) | ALDH1A1MAPTSMN1; SMN2CYP17A1POLB | |
| SCHEMBL2797644 | 0.81 | ALDH1A1 (0.47) | ALDH1A1KMT2AMEN1LMNAMAPT | |
| SCHEMBL1342005 | 0.80 | SMN1; SMN2 (0.61) | ALDH1A1KMT2AMEN1MAPTHTT | |
| SCHEMBL12085977 | 0.80 | CYP17A1 (0.51) | SMN1; SMN2CYP17A1HPGDPSMB8NAMPT | |
| SCHEMBL2795102 | 0.80 | ACACB (0.47) | ALDH1A1KMT2AMEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009144632-A1 | NOVEL COMPOUNDS | PFIZER LIMITED (GB) | 2009-12-03 | — | — | WO | disclosed |
| WO-2009144632-A1 | NOVEL COMPOUNDS | PFIZER LIMITED (GB) | 2009-12-03 | — | — | WO | disclosed |