Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MPI | P34949 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4326331 | 0.89 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1KDM4EDRD4DRD3 | |
| SCHEMBL4324271 | 0.87 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1KDM4ETSHRPOLB | |
| SCHEMBL4318788 | 0.87 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1KDM4ETSHRPOLB | |
| SCHEMBL4463803 | 0.85 | GAA (0.48) | SMN1; SMN2ALDH1A1KDM4EDRD4DRD3 | |
| SCHEMBL4471028 | 0.85 | HTR1A (0.57) | ALDH1A1KDM4EPOLBDRD4DRD3 | |
| SCHEMBL4329727 | 0.82 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1KDM4ETSHRPOLB | |
| SCHEMBL4341070 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1POLBDRD4DRD2 | |
| SCHEMBL4329231 | 0.81 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1KDM4EPOLBDRD4 | |
| SCHEMBL4326335 | 0.81 | DRD4 (0.53) | SMN1; SMN2ALDH1A1KDM4EPOLBDRD4 | |
| SCHEMBL4464690 | 0.81 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1KDM4ETSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069340-A1 | Pyrazolone Compounds As Metabotropic Glutamate Receptor Agonists For The Treatment Of Neurological And Psychiatric Disorders | ASTRAZENECA AB (SE) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069340-A1 | Pyrazolone Compounds As Metabotropic Glutamate Receptor Agonists For The Treatment Of Neurological And Psychiatric Disorders | GRIN1, GRM1, GRIN3A | SMN1; SMN2 1220/4885ALDH1A1 1785/4885KDM4E 3662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.