Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 3/20 | 0.50 |
| ▸ | PIM1 | P11309 | 12/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 8/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4594307 | 0.80 | PIM1 (0.70) | SCN5APIM1PIM2KCNH2RET | |
| SCHEMBL4339486 | 0.78 | SCN5A (0.51) | SCN5APIM1PIM2KCNH2RET | |
| SCHEMBL4885901 | 0.76 | FYN (0.52) | PIM1PIM2RET | |
| SCHEMBL4339013 | 0.76 | SCN5A (0.48) | SCN5APIM1PIM2KCNH2NTRK1 | |
| SCHEMBL4333814 | 0.74 | RET (0.59) | SCN5APIM1PIM2KCNH2RET | |
| Ammonia Solution, Strong SCHEMBL4594310 | 0.74 | SCN5A (0.53) | SCN5APIM1PIM2KCNH2FLT3 | |
| SCHEMBL4331109 | 0.72 | RET (0.47) | SCN5APIM1PIM2KCNH2RET | |
| SCHEMBL102242 | 0.71 | PIM1 (0.51) | SCN5APIM1PIM2KCNH2NTRK1 | |
| SCHEMBL4342695 | 0.70 | SCN5A (0.48) | SCN5APIM1PIM2KCNH2FLT3 | |
| SCHEMBL4330143 | 0.70 | FYN (0.57) | SCN5APIM1PIM2KCNH2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049539-A1 | PYRAZOLOPYRIMIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME. | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-04-22 | — | — | EP | claimed |
| WO-2007147647-A1 | PYRAZOLOPYRIMIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME. | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-12-27 | — | — | WO | claimed |