Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tetrylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrylammonium SCHEMBL28754153 | 0.97 | TDP1 (0.63) | TDP1PMP22KDM4EATMTSHR | |
| Hydrochloric Acid SCHEMBL662253 | 0.87 | TDP1 (0.50) | TDP1PMP22KDM4EATMTSHR | |
| Hydrochloric Acid SCHEMBL605741 | 0.85 | TDP1 (0.60) | TDP1PMP22ATMTSHRTHRB | |
| Tetrylammonium SCHEMBL29209200 | 0.84 | PMP22 (0.56) | TDP1PMP22KDM4EATMTSHR | |
| Hydrochloric Acid SCHEMBL27980318 | 0.83 | TDP1 (0.57) | TDP1PMP22ATMTSHRTHRB | |
| Water SCHEMBL29010291 | 0.83 | TDP1 (0.57) | TDP1PMP22ATMTSHRTHRB | |
| SCHEMBL4969427 | 0.82 | TDP1 (0.63) | TDP1PMP22ATMTSHRTHRB | |
| Tetrylammonium SCHEMBL27921045 | 0.82 | ATM (0.47) | TDP1PMP22KDM4EATMTSHR | |
| Propane SCHEMBL22974974 | 0.81 | — | — | |
| Propane SCHEMBL28309137 | 0.81 | TDP1 (0.80) | TDP1PMP22TSHRTHRBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598290-B2 | Cytotoxic agents comprising new C-2 modified taxanes | IMMUNOGEN, INC. (US) | 2009-10-06 | — | — | US | claimed |
| US-20070270482-A1 | Cytotoxic Agents Comprising New C-2 Modified Taxanes | AVENTIS PHARMA S.A. (FR) | 2007-11-22 | — | — | US | claimed |
| EP-1819687-A2 | CYTOTOXIC AGENTS COMPRISING NEW C-2 MODIFIED TAXANES | Aventis Pharma S.A. (FR) | 2007-08-22 | — | — | EP | claimed |
| EP-1688415-A1 | Cytotoxic agents comprising new C-2 modified taxanes | Aventis Pharma S.A. (FR) | 2006-08-09 | — | — | EP | claimed |
| WO-2006061259-A2 | CYTOTOXIC AGENTS COMPRISING NEW C-2 MODIFIED TAXANES | AVENTIS PHARMA S.A. (FR) | 2006-06-15 | — | — | WO | claimed |
| JP-5093071-A | — | — | None | — | — | JP | disclosed |
| CN-111909069-B | Degradable quaternary ammonium salt compound and preparation method and application thereof | 安徽启威生物科技有限公司 | 2022-04-19 | — | — | CN | disclosed |
| CN-111909069-A | Degradable quaternary ammonium salt compound and preparation method and application thereof | 安徽启威生物科技有限公司 | 2020-11-10 | — | — | CN | disclosed |
| US-7598290-B2 | Cytotoxic agents comprising new C-2 modified taxanes | IMMUNOGEN, INC. (US) | 2009-10-06 | — | — | US | disclosed |
| US-7422791-B2 | Joint assemblies, methods for installing joint assemblies, and jointing compositions | HALLSTAR INNOVATIONS CORP. (US) | 2008-09-09 | — | — | US | disclosed |
| US-20070270482-A1 | Cytotoxic Agents Comprising New C-2 Modified Taxanes | AVENTIS PHARMA S.A. (FR) | 2007-11-22 | — | — | US | disclosed |
| EP-1819687-A2 | CYTOTOXIC AGENTS COMPRISING NEW C-2 MODIFIED TAXANES | Aventis Pharma S.A. (FR) | 2007-08-22 | — | — | EP | disclosed |
| WO-1995033736-A1 | NEW TAXOIDS, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1995-12-14 | — | — | WO | disclosed |
| WO-1995033739-A1 | NEW TAXOIDS, PREPARATION THEREOF AND PHAMACEUTICAL COMPOSITIONS CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1995-12-14 | — | — | WO | disclosed |
| WO-1995033738-A1 | NEW TAXOIDS, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1995-12-14 | — | — | WO | disclosed |
| WO-1995026961-A1 | PROCESS FOR THE PREPARATION OF 7-HYDROXY TAXANES | RHONE-POULENC RORER S.A. (FR) | 1995-10-12 | — | — | WO | disclosed |
| US-5395817-A | N-pyridine substituted indoles | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-03-07 | — | — | US | disclosed |
| EP-0626946-A1 | N-PHENYLINDOLE AND N-PYRIDYLINDOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS HERBICIDES | ZENECA LIMITED (GB) | 1994-12-07 | — | — | EP | disclosed |
| WO-1993015049-A1 | N-PHENYLINDOLE AND N-PYRIDYLINDOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS HERBICIDES | ZENECA LIMITED (GB) | 1993-08-05 | — | — | WO | disclosed |
| JP-H0593071-A | SILICONE-CONTAINING HIGH POLYMER LATEX | ASAHI CHEM IND CO LTD | 1993-04-16 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270482-A1 | Cytotoxic Agents Comprising New C-2 Modified Taxanes | CCAR2, MCL1, CYTH2 | TDP1 1108/4885PMP22 2384/4885KDM4E 3979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.