Sugi Predict

Sugi Predict / Compounds / SCHEMBL4332910

SCHEMBL4332910

SCHEMBL4332910

NC(=S)N/N=C/c1cc(F)c(N2CCN(Cc3ccccc3C(F)(F)F)CC2)cc1F

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ MAOB P27338 1/20 0.43
▸ SCD O00767 1/20 0.43
▸ PHGDH O43175 1/20 0.42
▸ ALDH1A1 P00352 9/20 0.42
▸ KDM4E B2RXH2 8/20 0.42
▸ ATM Q13315 3/20 0.42
▸ TDP1 Q9NUW8 5/20 0.40
▸ NPSR1 Q6W5P4 3/20 0.40
▸ GAA P10253 1/20 0.40
▸ POLB P06746 1/20 0.40
▸ KMT2A Q03164 4/20 0.39
▸ MEN1 O00255 3/20 0.39
▸ HPGD P15428 1/20 0.38
▸ RECQL P46063 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ ALOX15 P16050 1/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.37
▸ TSHR P16473 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4332913 1.00 MAOB (0.43) MAOBSCDPHGDHALDH1A1KDM4E
SCHEMBL4324284 0.89 MAOB (0.50) MAOBPHGDHALDH1A1KDM4EGAA
SCHEMBL4324288 0.89 MAOB (0.50) MAOBPHGDHALDH1A1KDM4EGAA
SCHEMBL4338986 0.88 MAOB (0.42) MAOBALDH1A1KDM4EPOLBL3MBTL1
SCHEMBL4338982 0.88 MAOB (0.42) MAOBALDH1A1KDM4EPOLBL3MBTL1
SCHEMBL4323796 0.87 MAOB (0.45) MAOBPHGDHALDH1A1KDM4EATM
SCHEMBL4323793 0.87 MAOB (0.45) MAOBPHGDHALDH1A1KDM4EATM
SCHEMBL4343187 0.87 ALDH1A1 (0.48) MAOBPHGDHALDH1A1KDM4ETDP1
SCHEMBL4343182 0.87 ALDH1A1 (0.48) MAOBPHGDHALDH1A1KDM4ETDP1
SCHEMBL4327787 0.86 MAOB (0.41) MAOBALDH1A1KDM4ENPSR1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090285849-A1 Thiosemicarbazones as anti-virals and immunopotentiators NOVARTIS VACCINES AND DIAGNOSTICS, INC. 2009-11-19 — — US disclosed
US-20090285849-A1 Thiosemicarbazones as anti-virals and immunopotentiators NOVARTIS VACCINES AND DIAGNOSTICS, INC. 2009-11-19 — — US disclosed
US-20090285849-A1 Thiosemicarbazones as anti-virals and immunopotentiators NOVARTIS VACCINES AND DIAGNOSTICS, INC. 2009-11-19 — — US disclosed
US-7521062-B2 Thiosemicarbazones as anti-virals and immunopotentiators NOVARTIS VACCINES & DIAGNOSTICS, INC. (US) 2009-04-21 — — US disclosed
US-7521062-B2 Thiosemicarbazones as anti-virals and immunopotentiators NOVARTIS VACCINES & DIAGNOSTICS, INC. (US) 2009-04-21 — — US disclosed
US-7521062-B2 Thiosemicarbazones as anti-virals and immunopotentiators NOVARTIS VACCINES & DIAGNOSTICS, INC. (US) 2009-04-21 — — US disclosed
US-20050069555-A1 Thiosemicarbazones as anti-virals and immunopotentiators NOVARTIS VACCINES AND DIAGNOSTICS, INC. 2005-03-31 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090285849-A1 Thiosemicarbazones as anti-virals and immunopotentiators MAVS, IRF3, HAVCR2 MAOB 2762/4885SCD 2351/4885PHGDH 2500/4885
US-20050069555-A1 Thiosemicarbazones as anti-virals and immunopotentiators MAVS, IRF3, HAVCR2 MAOB 3093/4885SCD 2217/4885PHGDH 2768/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.