SCHEMBL4334243

SCHEMBL4334243

O=C1C2C3CC(C4OC34)C2C(=O)N1OS(=O)(=O)c1ccccc1C(F)(F)F

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.43
MEN1 O00255 1/20 0.43
LIPE Q05469 1/20 0.35
SLC22A12 Q96S37 6/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
CYP2C9 P11712 1/20 0.32
SLC22A6 Q4U2R8 1/20 0.32
SLC22A8 Q8TCC7 1/20 0.32
SLC22A11 Q9NSA0 1/20 0.32
F2 P00734 1/20 0.32
CTSS P25774 1/20 0.31
RXFP1 Q9HBX9 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4361781 0.88 KMT2A (0.45) KMT2AMEN1LIPESLC22A12L3MBTL1
SCHEMBL4831923 0.85 KMT2A (0.50) KMT2AMEN1LIPESLC22A12L3MBTL1
SCHEMBL29369448 0.84 KMT2A (0.46) KMT2AMEN1LIPESLC22A12ALDH1A1
SCHEMBL2069720 0.84 KMT2A (0.43) KMT2AMEN1LIPESLC22A12ALDH1A1
SCHEMBL29369870 0.84 KMT2A (0.43) KMT2AMEN1LIPESLC22A12ALDH1A1
SCHEMBL547625 0.84 KMT2A (0.46) KMT2AMEN1LIPESLC22A12ALDH1A1
SCHEMBL4837459 0.81 KMT2A (0.50) KMT2AMEN1LIPESLC22A12ALDH1A1
SCHEMBL4328998 0.75 KMT2A (0.47) KMT2AMEN1ALDH1A1LMNASMN1; SMN2
SCHEMBL3853026 0.74
SCHEMBL452741 0.74 PARL (0.57) KMT2AMEN1SLC22A12ALDH1A1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1489158-B1 Friction modifier composition SANYO CHEMICAL IND LTD (JP) 2012-06-20 EP disclosed
US-7579305-B2 Friction regulator for lubricating oil and lubricating oil composition SANYO CHEMICAL INDUSTRIES, LTD. (JP) 2009-08-25 US disclosed
US-20060105924-A1 Friction regulator for lubricating oil and lubricating oil composition SANYO CHEMICAL INDUSTRIES, LTD. (JP) 2006-05-18 US disclosed
EP-1489158-A1 FRICTION REGULATOR FOR LUBRICATING OIL AND LUBRICATING OIL COMPOSITION SANYO CHEMICAL INDUSTRIES, LTD. (JP) 2004-12-22 EP disclosed