SCHEMBL4334288

SCHEMBL4334288

OCCOc1ccc(-c2ccccc2)cc1Sc1cccc(F)c1

nearest known ligand 0.62

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
SLC6A9 P48067 18/20 0.62
HTR2C P28335 1/20 0.40
HTR2B P41595 1/20 0.40
ESR2 Q92731 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4343066 0.83 SLC6A9 (0.52) SLC6A9HTR2C
SCHEMBL4328709 0.81 SLC6A9 (0.81) SLC6A9
SCHEMBL4342739 0.81 SLC6A9 (0.63) SLC6A9
SCHEMBL4342734 0.81 SLC6A9 (0.63) SLC6A9
Hydrochloric Acid SCHEMBL4334265 0.80 SLC6A9 (0.62) SLC6A9
Hydrochloric Acid SCHEMBL4334272 0.80 SLC6A9 (0.62) SLC6A9
SCHEMBL4338317 0.78 ESR2 (0.49) SLC6A9ESR2
SCHEMBL4338278 0.78 SLC6A9 (1.00) SLC6A9
SCHEMBL4338281 0.78 SLC6A9 (1.00) SLC6A9
Hydrochloric Acid SCHEMBL4342585 0.77 SLC6A9 (0.98) SLC6A9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7612068-B2 Aromatic oxyphenyl and aromatic sulfanylphenyl derivatives H. LUNDBECK A/S (DK) 2009-11-03 US disclosed
US-20060235003-A1 Aromatic oxyphenyl and aromatic sulfanylphenyl derivatives H. LUNDBECK A/S (DK) 2006-10-19 US disclosed
EP-1622868-A1 AROMATIC OXYPHENYL AND AROMATIC SULFANYLPHENYL DERIVATIVES H. LUNDBECK A/S (DK) 2006-02-08 EP disclosed
WO-2004096761-A1 AROMATIC OXYPHENYL AND AROMATIC SULFANYLPHENYL DERIVATIVES H. LUNDBECK A/S (DK) 2004-11-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060235003-A1 Aromatic oxyphenyl and aromatic sulfanylphenyl derivatives TYR, TPST2, COMT SLC6A9 2305/4885HTR2C 31/4885HTR2B 89/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.