Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.40 |
| ▸ | CA1 | P00915 | 5/20 | 0.40 |
| ▸ | CA9 | Q16790 | 5/20 | 0.40 |
| ▸ | PADI4 | Q9UM07 | 7/20 | 0.38 |
| ▸ | PADI1 | Q9ULC6 | 5/20 | 0.38 |
| ▸ | PADI2 | Q9Y2J8 | 3/20 | 0.38 |
| ▸ | PADI3 | Q9ULW8 | 4/20 | 0.38 |
| ▸ | Q9HBH1 | 1/20 | 0.36 | |
| ▸ | NPY4R | P50391 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6762932 | 1.00 | CA12 (0.40) | CA12CA1CA9PADI4PADI1 | |
| Trifluoroacetic Acid SCHEMBL4324189 | 1.00 | CA12 (0.40) | CA12CA1CA9PADI4PADI1 | |
| Trifluoroacetic Acid SCHEMBL6761033 | 0.90 | CA12 (0.38) | CA12CA1CA9PDFCTSS | |
| SCHEMBL4332338 | 0.88 | CA1 (0.36) | CA12CA1CA9CTSSCTSK | |
| SCHEMBL4320796 | 0.88 | CA1 (0.36) | CA12CA1CA9CTSSCTSK | |
| SCHEMBL7719713 | 0.88 | CA1 (0.36) | CA12CA1CA9CTSSCTSK | |
| Trifluoroacetic Acid SCHEMBL4334971 | 0.87 | PADI4 (0.37) | CA12CA1CA9PADI4PADI1 | |
| Hydrochloric Acid SCHEMBL6758326 | 0.86 | CA1 (0.35) | CA12CA1CA9CTSSCTSK | |
| Trifluoroacetic Acid SCHEMBL6756463 | 0.85 | PDF (0.34) | CA12CA1CA9PDFCTSS | |
| Trifluoroacetic Acid SCHEMBL6758188 | 0.84 | PDF (0.39) | CA12CA1CA9PDFCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8664228-B2 | 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid derivatives and their use as epithelial sodium channel blockers for the treatment of airway diseases | NOVARTIS AG (CH) | 2014-03-04 | — | — | US | disclosed |
| EP-2285785-B1 | 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ARWAY DISEASES | NOVARTIS AG (CH) | 2012-09-05 | — | — | EP | disclosed |
| WO-2009138378-A1 | 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ARWAY DISEASES | NOVARTIS AG (CH) | 2009-11-19 | — | — | WO | disclosed |