Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PADI4 | Q9UM07 | 7/20 | 0.37 |
| ▸ | PADI1 | Q9ULC6 | 5/20 | 0.37 |
| ▸ | PADI2 | Q9Y2J8 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 4/20 | 0.37 |
| ▸ | CA1 | P00915 | 4/20 | 0.37 |
| ▸ | CA9 | Q16790 | 4/20 | 0.37 |
| ▸ | PADI3 | Q9ULW8 | 4/20 | 0.36 |
| ▸ | NPY4R | P50391 | 2/20 | 0.36 |
| ▸ | Q9HBH1 | 1/20 | 0.34 | |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5683578 | 0.87 | CA1 (0.34) | CA12CA1CA9CA2 | |
| SCHEMBL4320263 | 0.87 | CA1 (0.34) | CA12CA1CA9CA2 | |
| Trifluoroacetic Acid SCHEMBL4334998 | 0.87 | CA12 (0.40) | PADI4PADI1PADI2CA12CA1 | |
| Trifluoroacetic Acid SCHEMBL6762932 | 0.87 | CA12 (0.40) | PADI4PADI1PADI2CA12CA1 | |
| Trifluoroacetic Acid SCHEMBL4324189 | 0.87 | CA12 (0.40) | PADI4PADI1PADI2CA12CA1 | |
| Trifluoroacetic Acid SCHEMBL15414556 | 0.80 | PADI4 (0.34) | PADI4PADI1PADI2CA12CA1 | |
| Trifluoroacetic Acid SCHEMBL6761033 | 0.80 | CA12 (0.38) | CA12CA1CA9PDFCTSS | |
| SCHEMBL30471284 | 0.78 | EPHX1 (0.36) | PADI4PADI1PADI2CA12CA1 | |
| Trifluoroacetic Acid SCHEMBL4388550 | 0.78 | KDM4E (0.34) | PDFF2ITGB3ITGA2BDPP8 | |
| SCHEMBL29211036 | 0.77 | TGFBR1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8664228-B2 | 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid derivatives and their use as epithelial sodium channel blockers for the treatment of airway diseases | NOVARTIS AG (CH) | 2014-03-04 | — | — | US | disclosed |
| EP-2285785-B1 | 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ARWAY DISEASES | NOVARTIS AG (CH) | 2012-09-05 | — | — | EP | disclosed |
| WO-2009138378-A1 | 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ARWAY DISEASES | NOVARTIS AG (CH) | 2009-11-19 | — | — | WO | disclosed |