Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 2/20 | 0.31 |
| ▸ | CA5A | P35218 | 2/20 | 0.31 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4324192 | 1.00 | EPHX1 (0.39) | EPHX1ALDH1A1POLBSMN1; SMN2TAS1R3 | |
| SCHEMBL4334976 | 0.88 | EPHX1 (0.38) | EPHX1ALDH1A1POLBSMN1; SMN2MEN1 | |
| SCHEMBL21387098 | 0.74 | TAS1R3 (0.38) | ALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL4334897 | 0.73 | HDAC6 (0.34) | MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL1134627 | 0.73 | SCNN1A (0.41) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL27547888 | 0.73 | TAS1R3 (0.44) | EPHX1ALDH1A1POLBSMN1; SMN2TAS1R3 | |
| SCHEMBL23566512 | 0.70 | TAS1R3 (0.38) | TAS1R3TAS1R1CA12CA2CA9 | |
| SCHEMBL23566513 | 0.70 | TAS1R3 (0.38) | TAS1R3TAS1R1CA12CA2CA9 | |
| SCHEMBL23566651 | 0.70 | TAS1R3 (0.38) | TAS1R3TAS1R1CA12CA2CA9 | |
| SCHEMBL14191546 | 0.70 | DNM1 (0.39) | EPHX1ALDH1A1POLBSMN1; SMN2TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8664228-B2 | 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid derivatives and their use as epithelial sodium channel blockers for the treatment of airway diseases | NOVARTIS AG (CH) | 2014-03-04 | — | — | US | disclosed |
| EP-2285785-B1 | 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ARWAY DISEASES | NOVARTIS AG (CH) | 2012-09-05 | — | — | EP | disclosed |
| WO-2009138378-A1 | 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ARWAY DISEASES | NOVARTIS AG (CH) | 2009-11-19 | — | — | WO | disclosed |