Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Threonine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.31 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.34 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.31 |
| ▸ | GABRP | O00591 | 2/20 | 0.31 |
| ▸ | GABRD | O14764 | 2/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Threonine SCHEMBL28749680 | 0.86 | SLC7A5 (0.43) | SLC7A5USP2SLCO1B1TP53SLC1A3 | |
| Valine SCHEMBL9234038 | 0.85 | SLC7A5 (0.65) | SLC7A5MEN1LMNAKMT2AUSP2 | |
| Valine SCHEMBL3511172 | 0.85 | SLC7A5 (0.65) | SLC7A5MEN1LMNAKMT2AUSP2 | |
| Threonine SCHEMBL563849 | 0.82 | SLC7A5 (0.52) | SLC7A5USP2SLCO1B1TP53SLC1A3 | |
| Tromethamine SCHEMBL5524829 | 0.82 | MEN1 (0.50) | SLC7A5MEN1LMNAKMT2ATP53 | |
| Tromethamine SCHEMBL28614671 | 0.82 | TP53 (0.55) | SLC7A5MEN1LMNAKMT2ATP53 | |
| Threonine SCHEMBL117301 | 0.82 | — | — | |
| Threonine SCHEMBL18050155 | 0.82 | SLC7A5 (0.63) | SLC7A5USP2SLCO1B1TP53SLC1A3 | |
| Threonine SCHEMBL92730 | 0.82 | — | — | |
| Threonine SCHEMBL6038228 | 0.82 | SLC7A5 (0.63) | SLC7A5USP2SLCO1B1TP53SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2015726-A1 | COSMETIC COMPOSITION FOR STIMULATING THE SYNTHESIS OF PROTEINS OF THE BASEMENT MEMBRANE | DSMIP Assets B.V. (NL) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007124770-A1 | COSMETIC COMPOSITION FOR STIMULATING THE SYNTHESIS OF PROTEINS OF THE BASEMENT MEMBRANE | DSM IP ASSETS B.V. (NL) | 2007-11-08 | — | — | WO | disclosed |