Sugi Predict

Sugi Predict / Compounds / SCHEMBL4335537

SCHEMBL4335537

SCHEMBL4335537

CC(C)OC(Cc1ccc(COC(=O)Nc2ccc(F)cc2)cc1)C(=O)O

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 3/20 0.58
▸ MEN1 O00255 2/20 0.58
▸ SMN1; SMN2 Q16637 1/20 0.58
▸ L3MBTL1 Q9Y468 1/20 0.58
▸ PPARG P37231 7/20 0.48
▸ PPARA Q07869 7/20 0.48
▸ PPARD Q03181 4/20 0.48
▸ MGLL Q99685 1/20 0.46
▸ OPRK1 P41145 1/20 0.43
▸ ADORA3 P0DMS8 2/20 0.43
▸ ADORA2A P29274 2/20 0.43
▸ ADORA2B P29275 2/20 0.43
▸ ADORA1 P30542 2/20 0.43
▸ LMNA P02545 1/20 0.43
▸ RXFP1 Q9HBX9 1/20 0.43
▸ CYP1A2 P05177 1/20 0.42
▸ CYP2C19 P33261 1/20 0.42
▸ POLB P06746 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4341654 0.89 PPARG (0.48) KMT2AMEN1SMN1; SMN2L3MBTL1PPARG
SCHEMBL4329788 0.89 POLB (0.51) SMN1; SMN2PPARGPPARAPPARDMGLL
SCHEMBL4342690 0.88 PPARG (0.48) KMT2AMEN1SMN1; SMN2PPARGPPARA
SCHEMBL4327189 0.88 PPARG (0.48) KMT2AMEN1SMN1; SMN2PPARGPPARA
SCHEMBL4334181 0.88 MEN1 (0.52) KMT2AMEN1SMN1; SMN2L3MBTL1PPARG
SCHEMBL4347142 0.88 MEN1 (0.52) KMT2AMEN1SMN1; SMN2L3MBTL1PPARG
SCHEMBL4335156 0.87 NPC1 (0.50) KMT2ASMN1; SMN2PPARGPPARALMNA
SCHEMBL4332195 0.86 ALDH1A1 (0.47) KMT2AMEN1SMN1; SMN2L3MBTL1LMNA
SCHEMBL4335124 0.86 PPARG (0.54) KMT2AMEN1SMN1; SMN2L3MBTL1PPARG
SCHEMBL4327318 0.85 PPARA (0.52) KMT2AMEN1SMN1; SMN2PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-100522944-C Carboxylic acid derivatives and salts thereof EISAI CO LTD (JP) 2009-08-05 — — CN disclosed
US-7544835-B2 Carboxylic acid derivative and salt thereof EISAI R&D MANAGEMENT CO., LTD. (JP) 2009-06-09 — — US disclosed
US-7544835-B2 Carboxylic acid derivative and salt thereof EISAI R&D MANAGEMENT CO., LTD. (JP) 2009-06-09 — — US disclosed
US-7544835-B2 Carboxylic acid derivative and salt thereof EISAI R&D MANAGEMENT CO., LTD. (JP) 2009-06-09 — — US disclosed
CN-1503774-A Carboxylic acid derivatives and salts thereof ������������ʽ���� 2004-06-09 — — CN disclosed
US-20040102634-A1 Carboxylic acid derivative and salt thereof EISAI R&D MANAGEMENT CO., LTD. (JP) 2004-05-27 — — US disclosed
EP-1380562-A1 CARBOXYLIC ACID DERIVATIVE AND SALT THEREOF Eisai Co., Ltd. (JP) 2004-01-14 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040102634-A1 Carboxylic acid derivative and salt thereof GPR119, IRS1, SLC5A1 KMT2A 2774/4885MEN1 4091/4885SMN1; SMN2 3054/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.