SCHEMBL4336097

SCHEMBL4336097

O=C(O)CCc1ccccc1I

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KEAP1 Q14145 1/20 0.54
TAAR1 Q96RJ0 1/20 0.52
FFAR1 O14842 6/20 0.50
PTGER1 P34995 2/20 0.50
PTGER4 P35408 2/20 0.50
PTGER3 P43115 2/20 0.50
PTGER2 P43116 2/20 0.50
CYP1A2 P05177 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
PARP1 P09874 1/20 0.47
HDAC3 O15379 1/20 0.45
MAPK1 P28482 1/20 0.45
ADRA1A P35348 1/20 0.45
HDAC4 P56524 1/20 0.45
SLC6A3 Q01959 1/20 0.45
HDAC1 Q13547 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
HDAC7 Q8WUI4 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30403428 1.00 KEAP1 (0.54) KEAP1TAAR1FFAR1PTGER1PTGER4
SCHEMBL1964215 0.88 HDAC3 (0.57) KEAP1TAAR1FFAR1CYP1A2CYP2D6
SCHEMBL29381368 0.88 HDAC3 (0.57) KEAP1TAAR1FFAR1CYP1A2CYP2D6
SCHEMBL17593719 0.86 MAPT (0.56) KEAP1TAAR1CYP1A2CYP2D6CYP2C9
SCHEMBL28088495 0.85 TAAR1 (0.54) KEAP1TAAR1PTGER1PTGER4PTGER3
SCHEMBL290082 0.85 MAPT (0.59) TAAR1HDAC3MAPK1ADRA1AHDAC4
SCHEMBL59198 0.84 KEAP1 (0.65) KEAP1FFAR1PTGER1PTGER4PTGER3
SCHEMBL15379086 0.84 PARP1 (0.49) KEAP1FFAR1PTGER1PTGER4PTGER3
SCHEMBL17361342 0.82 IAPP (0.55) TAAR1CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL6474059 0.81 TAAR1 (0.46) KEAP1TAAR1PTGER1PTGER4PTGER3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020130080-A1 METHOD FOR PRODUCING P-QUINONES 学校法人立命館 2020-06-25 WO claimed
CN-114956933-A Marker containing isotope oxygen atom and preparation method and application thereof 清华大学 2022-08-30 CN disclosed
CN-111517902-B Aerobic oxidation system containing sulfinic acid, sulfonic acid or derivatives thereof and photo-oxidation promoting method thereof 清华大学 2022-06-14 CN disclosed
CN-112218913-A Porous body and method for producing porous body 株式会社伊玛尔斯京都 2021-01-12 CN disclosed
CN-111517902-A Aerobic oxidation system containing sulfinic acid, sulfonic acid or derivatives thereof and photo-oxidation promoting method thereof 清华大学 2020-08-11 CN disclosed
WO-2020155595-A1 AEROBIC OXIDATION SYSTEM CONTAINING SULFINIC ACID, SULFONIC ACID OR DERIVATIVES THEREOF AND PHOTOCATALYTIC OXIDATION METHOD THEREFOR 清华大学 2020-08-06 WO disclosed
WO-2020130080-A1 METHOD FOR PRODUCING P-QUINONES 学校法人立命館 2020-06-25 WO disclosed
EP-3474903-A1 DOUBLE TARGETED CONSTRUCTS TO AFFECT TUMOR KILL Cornell University (US) 2019-05-01 EP disclosed
WO-2017223357-A1 DOUBLE TARGETED CONSTRUCTS TO AFFECT TUMOR KILL CORNELL UNIVERSITY (US) 2017-12-28 WO disclosed
WO-2012168458-A1 ZWITTERIONIC COMPOUNDS USEFUL AS CATALYSTS FOR ESTERIFICATION REACTIONS AND PROCESSES FOR THEIR PRODUCTION ECOSYNTH BVBA (BE) 2012-12-13 WO disclosed
WO-1999058521-A1 11-ARYL-BENZO[B]NAPHTHO[2,3-D]FURANS AND 11-ARYL-BENZO[B]NAPHTHO[2,3-D]THIOPHENES USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA AMERICAN HOME PRODUCTS CORPORATION (US) 1999-11-18 WO disclosed
US-5849736-A Isoxazoline and isoxazole fibrinogen receptor antagonists THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) 1998-12-15 US disclosed
EP-0832076-A1 NOVEL ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1998-04-01 EP disclosed
EP-0544748-B1 SPIRO[CYCLOALKYLBENZENE-1,1'-(1',2',3',4'-TETRAHYDROISOQUINOLINES)] HAVING NEUROPROTECTIVE PROPERTIES ASTRA AB (SE) 1997-01-29 EP disclosed
WO-1996038426-A1 NOVEL ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1996-12-05 WO disclosed
EP-0730590-A1 NOVEL ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1996-09-11 EP disclosed
US-5472968-A Spiro[cycloalkylbenzene-1,1'-(1',2',3',4'-tetrahydro-isoquinolines)] having neuroprotective properties FISONS CORPORATION (US) 1995-12-05 US disclosed
WO-1995014683-A1 NOVEL ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1995-06-01 WO disclosed
EP-0544748-A1 SPIRO CYCLOALKYLBENZENE-1,1'-(1',2',3',4'-TETRAHYDROISOQUINOLINES)] HAVING NEUROPROTECTIVE PROPERTIES. FISONS CORP (US) 1993-06-09 EP disclosed
WO-1992003420-A1 SPIRO[CYCLOALKYLBENZENE-1,1'-(1',2',3',4'-TETRAHYDROISOQUINOLINES)] HAVING NEUROPROTECTIVE PROPERTIES FISONS CORPORATION (US) 1992-03-05 WO disclosed