Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3750000 | 0.99 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2ALDH1A1RXFP1 | |
| SCHEMBL3744263 | 0.80 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2ALDH1A1RXFP1 | |
| Hydrochloric Acid SCHEMBL3756459 | 0.79 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2ALDH1A1RXFP1 | |
| SCHEMBL3744427 | 0.78 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2ALDH1A1RXFP1 | |
| Hydrochloric Acid SCHEMBL3748830 | 0.77 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2ALDH1A1RXFP1 | |
| SCHEMBL3743854 | 0.74 | SIGMAR1 (0.43) | NPC1RAB9ASMN1; SMN2ALDH1A1RXFP1 | |
| SCHEMBL18344062 | 0.74 | RAB9A (0.49) | NPC1RAB9ASMN1; SMN2ALDH1A1RXFP1 | |
| SCHEMBL18344140 | 0.73 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2ALDH1A1RXFP1 | |
| SCHEMBL30028457 | 0.72 | RAB9A (0.59) | NPC1RAB9ASMN1; SMN2ALDH1A1RXFP1 | |
| SCHEMBL3747003 | 0.71 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2ALDH1A1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090170913-A1 | NOVEL MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY | 2009-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170913-A1 | NOVEL MCH RECEPTOR ANTAGONISTS | MCHR1, MCHR2, MC1R | NPC1 689/4885RAB9A 1154/4885SMN1; SMN2 2294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.