SCHEMBL4336571

SCHEMBL4336571

COC(=O)CCc1ccc(C(=O)CCc2sc(-c3ccc(C(F)(F)F)cc3)cc2C(C)C)cc1C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 7/20 0.40
PPARA Q07869 3/20 0.40
PPARG P37231 2/20 0.40
MAPT P10636 3/20 0.35
IDH1 O75874 2/20 0.34
FRK P42685 1/20 0.34
CAMK2B Q13554 1/20 0.34
CAMK2G Q13555 1/20 0.34
CAMK2D Q13557 1/20 0.34
FFAR1 O14842 1/20 0.33
GCGR P47871 1/20 0.33
GIPR P48546 1/20 0.33
MAPK11 Q15759 1/20 0.33
MAPK14 Q16539 1/20 0.33
CCR1 P32246 1/20 0.33
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
HSP90AA1 P07900 1/20 0.32
CRHBP P24387 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4327180 0.90 PPARD (0.47) PPARDPPARAPPARGFFAR1GCGR
SCHEMBL4097006 0.85 HSD17B1 (0.35) PPARDPPARAPPARGMAPTFRK
SCHEMBL4324880 0.83 PPARD (0.50) PPARDPPARAPPARGMAPTFFAR1
SCHEMBL30003690 0.82 PPARD (0.40) PPARDPPARAPPARG
SCHEMBL24656247 0.82 PPARD (0.40) PPARDPPARAPPARG
SCHEMBL1765904 0.81 PPARD (0.51) PPARDPPARAPPARG
SCHEMBL1765881 0.80 PPARA (0.47) PPARDPPARAPPARG
SCHEMBL30003517 0.80 PPARD (0.37) PPARDPPARAPPARGMAPT
SCHEMBL24656252 0.80 PPARD (0.37) PPARDPPARAPPARGMAPT
SCHEMBL1031012 0.79 PPARD (0.35) PPARDPPARAPPARGMAPTIDH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2014652-B1 ACTIVATING AGENT FOR PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR NIPPON CHEMIPHAR CO (JP) 2014-08-06 EP disclosed
US-20130217734-A1 ACTIVATING AGENT FOR PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA NIPPON CHEMIPHAR CO., LTD. (JP) 2013-08-22 US disclosed
US-8404726-B2 Activating agent for peroxisome proliferator activated receptor δ NIPPON CHEMIPHAR CO. LTD. (JP) 2013-03-26 US disclosed
US-20090298896-A1 ACTIVATING AGENT FOR PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA NIPPON CHEMIPHAR CO. LTD 2009-12-03 US disclosed
EP-2014652-A1 ACTIVATING AGENT FOR PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR Nippon Chemiphar Co., Ltd. (JP) 2009-01-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090298896-A1 ACTIVATING AGENT FOR PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA PPARA, PPARG, PPARD PPARD 3/4885PPARA 1/4885PPARG 2/4885
US-20130217734-A1 ACTIVATING AGENT FOR PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA PPARA, PPARG, PPARD PPARD 3/4885PPARA 1/4885PPARG 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.