Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.60 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.60 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.60 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.45 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.45 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | GABRR1 | P24046 | 3/20 | 0.41 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL725507 | 0.97 | TSHR (0.64) | TSHRLMNAEGLN1TP53ALKBH5 | |
| Fumaric Acid SCHEMBL4337403 | 0.97 | TSHR (0.64) | TSHRLMNAEGLN1TP53ALKBH5 | |
| Fumaric Acid SCHEMBL4337405 | 0.97 | TSHR (0.64) | TSHRLMNAEGLN1TP53ALKBH5 | |
| Maleic Acid SCHEMBL27498394 | 0.97 | TSHR (0.64) | TSHRLMNAEGLN1TP53ALKBH5 | |
| Fumaric Acid SCHEMBL4042291 | 0.97 | TSHR (0.64) | TSHRLMNAEGLN1TP53ALKBH5 | |
| Fumaric Acid SCHEMBL4042292 | 0.97 | TSHR (0.64) | TSHRLMNAEGLN1TP53ALKBH5 | |
| Fumaric Acid SCHEMBL4400079 | 0.97 | TSHR (0.64) | TSHRLMNAEGLN1TP53ALKBH5 | |
| Fumaric Acid SCHEMBL2390060 | 0.97 | TSHR (0.64) | TSHRLMNAEGLN1TP53ALKBH5 | |
| Maleic Acid SCHEMBL29222106 | 0.93 | TSHR (0.60) | TSHRLMNAEGLN1TP53ALKBH5 | |
| Maleic Acid SCHEMBL27558801 | 0.90 | TSHR (0.56) | TSHRLMNAEGLN1TP53ALKBH5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0264169-B1 | PROCESS FOR PRODUCING ETHYLENE-PROPYLENE COPOLYMER RUBBER | Tonen Corporation (JP) | 1990-11-22 | — | — | EP | disclosed |
| EP-0264169-A1 | Process for producing ethylene-propylene copolymer rubber | Tonen Corporation (JP) | 1988-04-20 | — | — | EP | disclosed |