Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 5/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1274517 | 1.00 | RIPK1 (0.36) | RIPK1HCAR3HCAR2MDM2TP53 | |
| SCHEMBL1274826 | 0.82 | RIPK1 (0.37) | RIPK1HCAR3HCAR2MDM2TP53 | |
| SCHEMBL12311280 | 0.80 | RIPK1 (0.33) | RIPK1 | |
| SCHEMBL12263102 | 0.78 | MDM2 (0.36) | RIPK1MDM2TP53 | |
| SCHEMBL6961509 | 0.76 | RIPK1 (0.37) | RIPK1TP53HTR7 | |
| SCHEMBL1068636 | 0.71 | RIPK1 (0.34) | RIPK1MDM2TP53 | |
| SCHEMBL978138 | 0.71 | RIPK1 (0.34) | RIPK1MDM2TP53 | |
| SCHEMBL1272344 | 0.68 | RIPK1 (0.38) | RIPK1HTR7 | |
| SCHEMBL1274500 | 0.67 | PGR (0.35) | — | |
| SCHEMBL1273295 | 0.67 | RIPK1 (0.41) | RIPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024358-A1 | SUBSTITUTED SPIROCYCLIC CGRP RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007133491-A1 | SUBSTITUTED SPIROCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2007-11-22 | — | — | WO | disclosed |