Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 9/20 | 0.49 |
| ▸ | AXL | P30530 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | CDK7 | P50613 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | FES | P07332 | 2/20 | 0.45 |
| ▸ | ROS1 | P08922 | 2/20 | 0.45 |
| ▸ | FER | P16591 | 2/20 | 0.45 |
| ▸ | FLT4 | P35916 | 2/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.45 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.45 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.45 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4338083 | 1.00 | CDK8 (0.49) | CDK8AXLKDRCDK7MAP4K4 | |
| SCHEMBL27752790 | 0.93 | CDK8 (0.48) | CDK8AXLKDRCDK7MAP4K4 | |
| SCHEMBL4342973 | 0.76 | BRD4 (0.35) | CDK8AXLKDRCDK7MAP4K4 | |
| SCHEMBL4346427 | 0.76 | BRD4 (0.35) | CDK8AXLKDRCDK7MAP4K4 | |
| SCHEMBL4342976 | 0.76 | BRD4 (0.35) | CDK8AXLKDRCDK7MAP4K4 | |
| SCHEMBL4344288 | 0.75 | CDK8 (0.55) | CDK8AXLKDRCDK7MAP4K4 | |
| SCHEMBL14319061 | 0.73 | CDK8 (0.50) | CDK8AXLKDRCDK7MAP4K4 | |
| SCHEMBL415994 | 0.73 | CDK8 (0.68) | CDK8KDRCDK7MAP4K4CHEK2 | |
| SCHEMBL211460 | 0.72 | TSHR (0.44) | — | |
| SCHEMBL27677303 | 0.72 | NAMPT (0.57) | CDK8AXLKDRCDK7MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090274674-A1 | Heterocyclic Oxime Compounds, Process for Their Preparation and Pharmaceutical Compositions Containing Them | LES LABORATOIRES SERVIER (FR) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090274674-A1 | Heterocyclic Oxime Compounds, Process for Their Preparation and Pharmaceutical Compositions Containing Them | CYP3A4, CYP2C19, CYP3A43 | CDK8 783/4885AXL 424/4885KDR 2050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.