Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 3/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | AXL | P30530 | 2/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | PAK4 | O96013 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | INSR | P06213 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4346427 | 1.00 | BRD4 (0.35) | BRD4CDK8TNKSALDH1A1SMN1; SMN2 | |
| SCHEMBL4342973 | 1.00 | BRD4 (0.35) | BRD4CDK8TNKSALDH1A1SMN1; SMN2 | |
| SCHEMBL27732329 | 0.88 | BRD4 (0.40) | BRD4CDK8AXLNUDT1KDR | |
| SCHEMBL4338082 | 0.76 | CDK8 (0.49) | BRD4CDK8AXLPLK4DCLK1 | |
| SCHEMBL4338083 | 0.76 | CDK8 (0.49) | BRD4CDK8AXLPLK4DCLK1 | |
| SCHEMBL4345671 | 0.73 | CNR2 (0.56) | CDK8TNKSALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL211460 | 0.71 | TSHR (0.44) | ALDH1A1SMN1; SMN2LMNAHTTTSHR | |
| SCHEMBL30487055 | 0.69 | CDK8 (0.43) | BRD4CDK8ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL1161415 | 0.69 | CDK8 (0.43) | BRD4CDK8ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL27752790 | 0.67 | CDK8 (0.48) | BRD4CDK8AXLNUDT1PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090274674-A1 | Heterocyclic Oxime Compounds, Process for Their Preparation and Pharmaceutical Compositions Containing Them | LES LABORATOIRES SERVIER (FR) | 2009-11-05 | — | — | US | disclosed |
| EP-1966204-A1 | NOVEL HETEROCYCLIC OXIME DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Les Laboratoires Servier (FR) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007077313-A1 | NOVEL HETEROCYCLIC OXIME DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2007-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090274674-A1 | Heterocyclic Oxime Compounds, Process for Their Preparation and Pharmaceutical Compositions Containing Them | CYP3A4, CYP2C19, CYP3A43 | BRD4 621/4885CDK8 783/4885TNKS 1890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.