Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Tocainide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A known ✓ | P35498 | 1/20 | 0.45 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 0.45 |
| ▸ | SCN3A known ✓ | Q9NY46 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | XIAP | P98170 | 2/20 | 0.49 |
| ▸ | BIRC2 | Q13490 | 2/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | ANPEP | P15144 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| S-Tocainide SCHEMBL308742 | 0.96 | ATM (0.57) | ATMHSP90AA1XIAPBIRC2TAAR1 | |
| Tocainide SCHEMBL15761 | 0.96 | ATM (0.57) | ATMHSP90AA1XIAPBIRC2TAAR1 | |
| Tocainide SCHEMBL9614374 | 0.95 | ATM (0.55) | ATMHSP90AA1XIAPBIRC2TAAR1 | |
| Tocainide SCHEMBL122779 | 0.95 | ATM (0.55) | ATMHSP90AA1XIAPBIRC2TAAR1 | |
| Tocainide SCHEMBL27874301 | 0.91 | ATM (0.53) | ATMHSP90AA1XIAPBIRC2TAAR1 | |
| SCHEMBL11423763 | 0.83 | NLRP3 (0.52) | ATMANPEPALDH1A1MEN1KMT2A | |
| SCHEMBL11436632 | 0.82 | ATM (0.54) | ATMHSP90AA1ANPEPDRD2HTR2A | |
| SCHEMBL12832472 | 0.81 | ATM (0.60) | ATMHSP90AA1ANPEPDRD2HTR2A | |
| Tocainide SCHEMBL13724527 | 0.81 | SCN4A (0.65) | ATMHSP90AA1ANPEPHTR2AHTR2B | |
| SCHEMBL6356591 | 0.79 | ATM (0.58) | ATMHSP90AA1ANPEPDRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021502-A1 | NOVEL GENES AND MARKERS IN TYPE 2 DIABETES AND OBESITY | Oy Jurilab Ltd (FI) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007128884-A1 | NOVEL GENES AND MARKERS IN TYPE 2 DIABETES AND OBESITY | OY JURILAB LTD (FI) | 2007-11-15 | — | — | WO | disclosed |