Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2073708 | 0.87 | PKM (0.49) | PKMKDM4EGAAHSD17B10KMT2A | |
| SCHEMBL2076920 | 0.87 | KDR (0.49) | KDRKDM4EGAAHSD17B10KMT2A | |
| SCHEMBL1741589 | 0.86 | KDR (0.51) | KDRKDM4EGAAHSD17B10KMT2A | |
| SCHEMBL1741794 | 0.86 | KDR (0.51) | KDRKDM4EGAAHSD17B10KMT2A | |
| SCHEMBL1741752 | 0.86 | PKM (0.48) | PKMKDM4EGAAHSD17B10KMT2A | |
| SCHEMBL1742916 | 0.86 | KDR (0.51) | KDRKDM4EGAAHSD17B10KMT2A | |
| SCHEMBL1740693 | 0.86 | PKM (0.48) | PKMKDM4EGAAHSD17B10KMT2A | |
| SCHEMBL1742738 | 0.86 | PKM (0.48) | PKMKDM4EGAAHSD17B10KMT2A | |
| SCHEMBL1740452 | 0.86 | KDR (0.51) | KDRKDM4EGAAHSD17B10KMT2A | |
| SCHEMBL11899586 | 0.86 | PKM (0.48) | PKMKDM4EGAAHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024360-A2 | SUBSTITUTED PYRAZOLOPYRIMIDINES | Cephalon, Inc. (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2008063232-A2 | SUBSTITUTED PYRAZOLOPYRIMIDINES | CEPHALON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |