Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 6/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.50 |
| ▸ | HTR1A | P08908 | 3/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | VEGFA | P15692 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27447653 | 0.89 | SLC6A2 (0.47) | SLC6A4SLC6A2SLC6A3HTR1ASLC1A5 | |
| SCHEMBL6290334 | 0.86 | SLC6A4 (0.57) | SLC6A4SLC6A2SLC6A3HTR1ASLC1A5 | |
| SCHEMBL8969033 | 0.86 | AR (0.49) | ARTTRUSP2KMT2ACA1 | |
| SCHEMBL6290645 | 0.84 | SLC6A4 (0.55) | SLC6A4SLC6A2SLC6A3HTR1ASLC1A5 | |
| SCHEMBL6290492 | 0.84 | SLC6A4 (0.55) | SLC6A4SLC6A2SLC6A3HTR1ASLC1A5 | |
| SCHEMBL6293111 | 0.84 | SLC6A4 (0.55) | SLC6A4SLC6A2SLC6A3HTR1ASLC1A5 | |
| SCHEMBL6290672 | 0.84 | SLC6A4 (0.55) | SLC6A4SLC6A2SLC6A3HTR1ASLC1A5 | |
| SCHEMBL6289276 | 0.82 | SLC6A4 (0.54) | SLC6A4SLC6A2SLC6A3HTR1ASLC1A5 | |
| SCHEMBL6289809 | 0.82 | SLC6A4 (0.54) | SLC6A4SLC6A2SLC6A3HTR1ASLC1A5 | |
| SCHEMBL6290677 | 0.82 | SLC6A4 (0.54) | SLC6A4SLC6A2SLC6A3HTR1ASLC1A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10329270-B2 | Heteroaryl compounds as BTK inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2019-06-25 | — | — | US | disclosed |
| EP-3060550-B1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-05-15 | — | — | EP | disclosed |
| US-20160264548-A1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2016-09-15 | — | — | US | disclosed |
| EP-3060550-A2 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | Merck Patent GmbH (DE) | 2016-08-31 | — | — | EP | disclosed |
| WO-2015061247-A2 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2015-04-30 | — | — | WO | disclosed |
| US-7612068-B2 | Aromatic oxyphenyl and aromatic sulfanylphenyl derivatives | H. LUNDBECK A/S (DK) | 2009-11-03 | — | — | US | disclosed |
| US-20060235003-A1 | Aromatic oxyphenyl and aromatic sulfanylphenyl derivatives | H. LUNDBECK A/S (DK) | 2006-10-19 | — | — | US | disclosed |
| CN-1225456-C | Novel aromatic diamine and its polyimide | MITSUI CHEMICALS INC (JP) | 2005-11-02 | — | — | CN | disclosed |
| CN-1403438-A | Novel aromatic diamine and its polyimide | MITSUI CHEMICALS INC (JP) | 2003-03-19 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160264548-A1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | BTK, SYK, LCK | SLC6A4 4620/4885SLC6A2 4582/4885SLC6A3 4564/4885 |
| US-20060235003-A1 | Aromatic oxyphenyl and aromatic sulfanylphenyl derivatives | TYR, TPST2, COMT | SLC6A4 22/4885SLC6A2 16/4885SLC6A3 8/4885 |
| US-10329270-B2 | Heteroaryl compounds as BTK inhibitors and uses thereof | BTK, SYK, LCK | SLC6A4 4620/4885SLC6A2 4582/4885SLC6A3 4564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.