Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 5/20 | 0.71 |
| ▸ | SRC | P12931 | 3/20 | 0.71 |
| ▸ | DHFR | P00374 | 4/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5619139 | 0.84 | FGFR1 (1.00) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL975784 | 0.82 | CYP2D6 (0.57) | FGFR1SRCDHFR | |
| SCHEMBL4186547 | 0.81 | DHFR (0.56) | FGFR1SRCDHFR | |
| SCHEMBL4200127 | 0.79 | FGFR1 (0.71) | FGFR1SRCDHFREGFRFGFR2 | |
| SCHEMBL8129675 | 0.75 | FGFR1 (0.82) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL5765344 | 0.75 | FGFR1 (0.74) | FGFR1SRCEGFRFGFR2FGFR4 | |
| Pyrimidine SCHEMBL3091353 | 0.75 | PTPN11 (0.49) | FGFR1SRCDHFR | |
| SCHEMBL1388562 | 0.74 | DHFR (1.00) | FGFR1SRCDHFR | |
| SCHEMBL29913330 | 0.74 | DHFR (1.00) | FGFR1SRCDHFR | |
| SCHEMBL21223541 | 0.73 | FGFR1 (0.53) | FGFR1SRCEGFRFGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032543-A1 | 2-ANILINO-4-AMINOALKYLENEAMINOPYRIMIDINES | Boehringer Ingelheim International GmbH (DE) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007146977-A1 | 2-ANILINO-4-AMINOALKYLENEAMINOPYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-12-21 | — | — | WO | disclosed |