Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 10/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.53 |
| ▸ | MAPK3 | P27361 | 6/20 | 0.51 |
| ▸ | DCAF1 | Q9Y4B6 | 1/20 | 0.48 |
| ▸ | TACR3 | P29371 | 3/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | AKT2 | P31751 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4333011 | 0.88 | MAPK1 (0.51) | MAPK1ROCK1ROCK2MAPK3MAPK13 | |
| SCHEMBL4334123 | 0.87 | ROCK2 (0.43) | MAPK1ROCK1ROCK2MAPK3TACR3 | |
| SCHEMBL2861653 | 0.85 | MAPK1 (0.74) | MAPK1ROCK1ROCK2MAPK3PAK4 | |
| SCHEMBL4335964 | 0.83 | TRPV3 (0.42) | MAPK1ROCK1ROCK2MAPK3PAK4 | |
| SCHEMBL4346841 | 0.82 | ROCK1 (0.41) | MAPK1ROCK1ROCK2MAPK3 | |
| SCHEMBL4335876 | 0.80 | MAPK1 (0.56) | MAPK1ROCK1ROCK2MAPK3DCAF1 | |
| SCHEMBL4341423 | 0.80 | ROCK1 (0.39) | MAPK1ROCK1ROCK2MAPK3 | |
| SCHEMBL4334510 | 0.79 | MAPK1 (0.39) | MAPK1ROCK1ROCK2MAPK3TACR3 | |
| SCHEMBL2861586 | 0.79 | MAP2K4 (0.56) | MAPK1 | |
| SCHEMBL4340620 | 0.78 | ROCK1 (0.39) | MAPK1ROCK1ROCK2MAPK3DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776890-B2 | 1H-indazole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-17 | — | — | US | disclosed |
| US-7776890-B2 | 1H-indazole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-17 | — | — | US | disclosed |
| EP-1380576-B1 | 1H-INDAZOLE COMPOUNDS INHIBITING JNK | EISAI R&D MAN CO LTD (JP) | 2009-11-25 | — | — | EP | disclosed |
| US-20090203691-A1 | Novel 1H-indazole compounds | OINUMA HITOSHI | 2009-08-13 | — | — | US | disclosed |
| US-20090203691-A1 | Novel 1H-indazole compounds | OINUMA HITOSHI | 2009-08-13 | — | — | US | disclosed |
| US-7541376-B2 | 1H-indazole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-02 | — | — | US | disclosed |
| US-20050282880-A1 | Novel 1H-indazole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203691-A1 | Novel 1H-indazole compounds | MAPK1, MAPK3, MAPK13 | MAPK1 1/4885ROCK1 504/4885ROCK2 805/4885 |
| US-20050282880-A1 | Novel 1H-indazole compounds | MAPK1, MAPK3, MAPK13 | MAPK1 1/4885ROCK1 504/4885ROCK2 805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.